3.0
Summary
| Name |  ERRFI1View Modifications |
| Full Name | ERBB receptor feedback inhibitor 1 |
| Synonyms | Mitogen-inducible gene 6 protein, MIG-6 | MIG6 |
| Primary ID | Q9UJM3 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | EGFR Signaling |
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EGFR | up-regulates activity 
phosphorylation
|
ERRFI1 | 0.662 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | EGFR Signaling | |||
| + | ERRFI1 | down-regulates activity 
binding
|
EGFR | 0.662 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | EGFR Signaling | |||
| + | ERRFI1 | down-regulates quantity by destabilization
binding
|
EGFR | 0.662 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | EGFR Signaling | |||
| + | ERRFI1 | down-regulates activity
binding
|
ERBB2 | 0.735 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ERRFI1 | down-regulates
binding
|
EGFR | 0.662 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| Pathways: | EGFR Signaling | |||