| + |
TUBE1 | up-regulates 
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267178 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28347630 |
Microtubules are essential for the generation, migration and differentiation of neurons. Within dendrites microtubules have also been implicated in the formation and plasticity of spines. For instance, the treatment of hippocampal neurons with low doses of the microtubule destabilizing drug Nocodazole impairs BDNF induced dendritic spine formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
vincaleukoblastine sulfate | down-regulates activity 
chemical inhibition
|
TUBE1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15579115 |
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KATNAL2 | down-regulates quantity by destabilization
binding
|
TUBE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267176 |
|
|
Mus musculus |
Testis |
| pmid |
sentence |
| 29136647 |
KATNAL2 does not sever microtubules composed of α- and β-tubulin but does interact with δ- and ε-tubulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
TUBE1
- 
- 