| + |
ANAPC2 | down-regulates 
binding
|
DVL1 |
0.241 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19805045 |
We now report that the anaphase-promoting complex (apc/c) recognizes a d-box motif of dvl and ubiquitylates dvl on a highly conserved lysine residue.We now report that expression of the apc/c subunit anapc2 activates the apc/c-dependent degradation of dvl by disrupting canonical wnt signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANAPC2 | form complex 
binding
|
APC-c |
0.87 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252002 |
|
|
|
|
| pmid |
sentence |
| 16896351 |
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. |
|
| Publications: |
1 |
| + |
NAE | up-regulates activity 
neddylation
|
ANAPC2 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25504797 |
The family of cullin proteins is the most established target for NEDD8. In humans, it is composed of seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), whereas PARC (CUL9) and APC2 (component of the anaphase promoting complex APC) contain a cullin-homology domain. All cullins are modified with NEDD8The role of cullin NEDDylation is to enhance the activity of the CRLs and subsequent ubiquitination and degradation of the regulated substrates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ANAPC2
- 
- 