| + |
LCK | up-regulates activity 
phosphorylation
|
DAPP1 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249373 |
Tyr139 |
KVEEPSIyESVRVHT |
|
|
| pmid |
sentence |
| 10880360 |
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins. |
|
| Publications: |
1 |
| + |
SRC | up-regulates activity
phosphorylation
|
DAPP1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247119 |
Tyr139 |
KVEEPSIyESVRVHT |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 10880360 |
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell linesyrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LYN | up-regulates activity
phosphorylation
|
DAPP1 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249378 |
Tyr139 |
KVEEPSIyESVRVHT |
|
B-lymphocyte |
| pmid |
sentence |
| 10880360 |
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins. |
|
| Publications: |
1 |
| + |
BTK | up-regulates activity
phosphorylation
|
DAPP1 |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249313 |
Tyr139 |
KVEEPSIyESVRVHT |
|
B-lymphocyte |
| pmid |
sentence |
| 10880360 |
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential binding site for Src homology 2 domain-containing proteins. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250602 |
Tyr139 |
KVEEPSIyESVRVHT |
in vitro |
|
| pmid |
sentence |
| 11524430 |
We present a number of lines of evidence that in vivo, Src-type tyrosine kinases are responsible for the phosphorylation of tyrosine 139 in DAPP-1. | Although Btk appears to phosphorylate DAPP-1 relatively efficiently both in Sf9 cells and in vitro, we find no evidence that in either B cells or PAE cells Btk family kinases phosphorylate DAPP-1. |
|
| Publications: |
2 |
Organism: |
, In Vitro |
4.0
DAPP1
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