3.0
Summary
| Name |  CILK1View Modifications |
| Full Name | Serine/threonine-protein kinase ICK |
| Synonyms | Intestinal cell kinase, hICK, Laryngeal cancer kinase 2, LCK2, MAK-related kinase, MRK | KIAA0936 |
| Primary ID | Q9UPZ9 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP2CA | down-regulates 
dephosphorylation
|
CILK1 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PPP5C | down-regulates activity
dephosphorylation
|
CILK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK20 | up-regulates 
phosphorylation
|
CILK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CILK1 | up-regulates
phosphorylation
|
RPTOR | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FGFR3 | down-regulates activity
phosphorylation
|
CILK1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CILK1 | up-regulates
phosphorylation
|
CILK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CILK1 | up-regulates
phosphorylation
|
mTORC1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |