Relation Results

Summary

Name YARS2
Full Name Tyrosine--tRNA ligase, mitochondrial
Synonyms Tyrosyl-tRNA synthetase, TyrRS |
Primary ID Q9Y2Z4
Links - -
Type protein
Relations 2
Function Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction

Viewer

Type: Score: Layout: SPV 
0.20.2QRICH1YARS2ATF4

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ QRICH1up-regulates quantity by expression img/direct-activation.png transcriptional regulation YARS2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269413 Homo sapiens
pmid sentence
QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 and ATF4 modulate tRNA metabolic processes to promote secreted protein synthesis during ER stress.
Publications: 1 Organism: Homo Sapiens
+ ATF4up-regulates quantity by expression img/direct-activation.png transcriptional regulation YARS2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269432 Homo sapiens
pmid sentence
QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 and ATF4 modulate tRNA metabolic processes to promote secreted protein synthesis during ER stress.
Publications: 1 Organism: Homo Sapiens
a simple tooltip