4.0
Summary
| Name |  RNF115View Modifications |
| Full Name | E3 ubiquitin-protein ligase RNF115 |
| Synonyms | RING finger protein 115, RING-type E3 ubiquitin transferase RNF115, Rabring 7, Zinc finger protein 364 | ZNF364 |
| Primary ID | Q9Y4L5 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RNF115 | down-regulates quantity by destabilization 
ubiquitination
|
MYC | 0.448 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF115 | down-regulates quantity by destabilization
polyubiquitination
|
EGFR | 0.374 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
RNF115 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |