| + |
PPME1 | down-regulates activity 
demethylation
|
PPP2CB |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265750 |
Leu309 |
RRTPDYFl |
in vitro |
|
| pmid |
sentence |
| 18394995 |
Methylation of the carboxy-terminal Leu309 in a conserved TPDYFL309 motif of the C subunit has been shown to enhance the affinity of the PP2A core enzyme for some, but not all, regulatory subunits |Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from yeast to humans. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPME1 | down-regulates activity
demethylation
|
PPP2CA |
0.902 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265748 |
Leu309 |
RRTPDYFl |
in vitro |
|
| pmid |
sentence |
| 18394995 |
Methylation of the carboxy-terminal Leu309 in a conserved TPDYFL309 motif of the C subunit has been shown to enhance the affinity of the PP2A core enzyme for some, but not all, regulatory subunits |Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from yeast to humans. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PP2CA_R1A_R2A | up-regulates activity 
dephosphorylation
|
PPME1 |
0.815 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265752 |
Ser15 |
MHLGRLPsRPPLPGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24841198 |
The results subsequently revealed that phosphorylated PME-1/Ser15 is dephosphorylated by SIK2·PP2A (Fig. 5G). |Our results also demonstrated that the phosphorylated levels of PME-1/Ser15 and CaMKI/Thr177 are inversely correlated with the phosphatase activity of SIK2·PP2A complex, further implying that the demethylase activity of phosphorylated PME-1/Ser15 may be higher than that of its unphosphorylated state. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK1 | up-regulates activity
phosphorylation
|
PPME1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276636 |
Ser15 |
MHLGRLPsRPPLPGS |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 24841198 |
When the CaMKI activity is elevated, it phosphorylates PME-1 at Ser15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK1 | down-regulates activity
phosphorylation
|
PPME1 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265747 |
Ser15 |
MHLGRLPsRPPLPGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24841198 |
CaMKI Is the Upstream Kinase for Phosphorylation of PME-1/Ser15|Our results also demonstrated that the phosphorylated levels of PME-1/Ser15 and CaMKI/Thr177 are inversely correlated with the phosphatase activity of SIK2·PP2A complex, further implying that the demethylase activity of phosphorylated PME-1/Ser15 may be higher than that of its unphosphorylated state. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPME1
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