Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261670 |
|
|
Homo sapiens |
|
pmid |
sentence |
32761762 |
Here, we show that the previously undescribed CSAG2 protein is a direct activator of SIRT1. Biochemical studies revealed that CSAG2 directly binds to and stimulates SIRT1 activity toward multiple substrates. Importantly, CSAG2 enhances SIRT1‐mediated deacetylation of p53, inhibits p53 transcriptional activity, and improves cell survival in response to genotoxic stress. |
|