3.0
Summary
| Name |  USP16View Modifications |
| Full Name | Ubiquitin carboxyl-terminal hydrolase 16 |
| Synonyms | Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16 |
| Primary ID | Q9Y5T5 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | up-regulates activity 
phosphorylation
|
USP16 | 0.344 |
| Publications: | 4 | Organism: | In Vitro, Homo Sapiens | |
| + | TTK | down-regulates quantity by destabilization 
phosphorylation
|
USP16 | 0.371 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
USP16 | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP16 | down-regulates activity
deubiquitination
|
Histone H2A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |