| + |
Polycomb repressive complex 2 | up-regulates activity 
methylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260449 |
Lys28 |
LATKAARkSAPATGG |
Homo sapiens |
|
| pmid |
sentence |
| 24987060 |
The presence of trimethylation of H3K27 (H3K27me3) at promoter regions is associated with gene repression. This modification is generated by the Polycomb repressive complex 2 (PRC2), composed of the SET domain-containing histone methyltransferase (HMT) EZH2 (enhancer of zeste homolog 2) or its functional homologue EZH1, and core accessory proteins (EED, SUZ12, and RbAp48) (Fig. 1A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | up-regulates activity
methylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265367 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24987060 |
The presence of trimethylation of H3K27 (H3K27me3) at promoter regions is associated with gene repression. This modification is generated by the Polycomb repressive complex 2 (PRC2), composed of the SET domain-containing histone methyltransferase (HMT) EZH2 (enhancer of zeste homolog 2) or its functional homologue EZH1, and core accessory proteins (EED, SUZ12, and RbAp48) (Fig. 1A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATRX | up-regulates activity
binding
|
Polycomb repressive complex 2 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25417162 |
ATRX is a required specificity determinant for PRC2 targeting and function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates activity 
|
KDM5B |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35217626 |
Our transcriptomic profiling in AML further identified Kdm5b (also known as Jarid1b, Plu-1, or RBP2-H1), a multifunctional demethylase that can remove histone H3 lysine 4 tri/di-methylation (H3K4me3/2), to be a critical downstream target repressed by PRC2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASXL1 | up-regulates activity
binding
|
Polycomb repressive complex 2 |
0.581 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255923 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 22897849 |
These data led us to hypothesize that ASXL1 interacts with the PRC2 complex; co-immunoprecipitation studies revealed that ASXL1 associates with members of the PRC2 complex including EZH2 and SUZ12 but not with the PRC1 repressive complex. Importantly, ASXL1 downregulation resulted in loss of EZH2 recruitment to the HOXA locus indicating a role of ASXL1 in recruiting the PRC2 complex to known leukemogenic loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22469984 |
The requirement for PRC2 in leukemia is partly because of its role in direct transcriptional repression of genes that limit the self-renewal potential of hematopoietic cells, including Cdkn2a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates quantity by repression 
transcriptional regulation
|
HOXA9 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20565746 |
These data support the proposed regulatory impact of particular PRC2-proteins in expression of HOXA9 and HOXA10 in NK/T-cells. In mammalian cells knockdown of PRC2 components EZH2 or PHF1 led to upregulated HOXA gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22469984 |
The requirement for PRC2 in leukemia is partly because of its role in direct transcriptional repression of genes that limit the self-renewal potential of hematopoietic cells, including Cdkn2a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EED | form complex 
binding
|
Polycomb repressive complex 2 |
0.905 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241897 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AEBP2 | form complex
binding
|
Polycomb repressive complex 2 |
0.87 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241903 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | form complex
binding
|
Polycomb repressive complex 2 |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUZ12 | form complex
binding
|
Polycomb repressive complex 2 |
0.928 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GTF2I | up-regulates activity
relocalization
|
Polycomb repressive complex 2 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268543 |
|
|
|
|
| pmid |
sentence |
| 17970752 |
We demonstrate that Suz12, a component of the polycomb repressor complex 2, is recruited to the beta-globin gene.| Our data suggest that TFII-I contributes to the recruitment of the polycomb repressor complex 2 complex to the beta-globin gene. |
|
| Publications: |
1 |
| + |
YY1 | up-regulates quantity by expression
|
Polycomb repressive complex 2 |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253595 |
|
|
|
|
| pmid |
sentence |
| 17158804 |
YY1 REPO domain is necessary and sufficient for PcG transcriptional repression, Polycomb recruitment to DNA, and methylation of histone H3 on lysine 27 |
|
| Publications: |
1 |
| + |
RBBP4 | form complex
binding
|
Polycomb repressive complex 2 |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241906 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates quantity by repression
transcriptional regulation
|
PAX7 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253598 |
|
|
|
|
| pmid |
sentence |
| 20887952 |
The results presented above demonstrate a signal-dependent interaction between p38a, YY1, and EZH2 on the chromatin of the Pax7 regulatory elements that coincides with p38-mediated repression of Pax7 at early stages of myoblast differentiation. |
|
| Publications: |
1 |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
Polycomb repressive complex 2 |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253599 |
|
|
Cricetulus griseus |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 20887952 |
The chromatin redistribution of PRC2 in differentiating SCs is regulated by the p38a kinase, which promotes the formation of a complex containing p38a, EZH2, and YY1, via direct phosphorylation of EZH2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
Polycomb repressive complex 2 | down-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21248841 |
The importance of polycomb function for stem cells is best illustrated by various PcG-knockout mice. Deletion of any of the PRC2 members results in embryonic lethality. In vitro studies with ES cells demonstrated that cells lacking EED or Suz12 could not maintain their pluripotency and were prone to differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Polycomb repressive complex 2 | down-regulates
|
Epigenetic_regulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22303254 |
Polycomb group (PcG) and Trithorax group (TrxG) proteins are epigenetic regulators that control gene expression through modulating chromatin structure and addition of posttranslational modifications (PTMs) on histones |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Polycomb repressive complex 2