Relation Results

Summary

Name Epigenetic_regulation
Primary ID SIGNOR-PH203
Type phenotype
Description Epigenetic regulation is a process by which the activity of a gene is modulated by chromatin structure.
Relations 17

Viewer

Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.7Polycomb repressive complex 2Epigenetic_regulationSWI/SNF complexRESTMuscle cell-specific SWI/SNF SMARCA4 variantMuscle cell-specific SWI/SNF ARID1A variantKDM1AGBAFHDAC2Embryonic stem cell-specific SWI/SNFBrain-specific SWI/SNF SMARCA2 variantSETD5Neural progenitor-specific SWI/SNFKMT2ABrain-specific SWI/SNF SMARCA4 variantSWI/SNF ACTL6B varianSWI/SNF ACTL6A-ARID1A-SMARCA2 variant

Relations

Regulator
Mechanism
target
score
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268625 Homo sapiens
pmid sentence
Polycomb group (PcG) and Trithorax group (TrxG) proteins are epigenetic regulators that control gene expression through modulating chromatin structure and addition of posttranslational modifications (PTMs) on histones
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268623 Homo sapiens
pmid sentence
Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. 
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268622 Homo sapiens
pmid sentence
NRSF represses neuronal differentiation by binding to conserved NRS elements (NRSEs) in gene promoters in non-neuronal cells, where it associates with one of several large repressor complexes, including the transcriptional co-repressor mSIN3a/b, nuclear receptor co-repressor 1 (N-CoR1), and coREST/histone deacetylase 2 (HDAC2). In this way, NRSF keeps neural-specific genes turned off in non-neuronal cells.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270741 Homo sapiens
pmid sentence
The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. 
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270713 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Identifier Residue Sequence Organism Cell Line
SIGNOR-270700 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268728 Homo sapiens
pmid sentence
The Lysine-specific demethylase 1, KDM1A/LSD1, plays a central role in the regulation of Pol II transcription through the removal of the activation mark (mono- and dimethyl lysine 4 of histone H3). LSD1 is often deregulated in human cancers, and it is frequently overexpressed in human solid cancers and leukemia.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269790 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268624 Homo sapiens
pmid sentence
Among histone-modifying enzymes, HDAC2 is a crit- ical negative regulator of structural and functional plasticity in the mammalian nervous system (Guan et al., 2009; Hanson et al., 2013). HDAC2 localizes to the promoters of numerous synap- tic-plasticity-associated genes, where it deacetylates histone substrates (Gra ̈ ff et al., 2012; Guan et al., 2009). Consistently, loss of HDAC2 or HDAC inhibitor treatments promotes synaptic gene expression, long-term synaptic plasticity, and memory pro- cesses, while HDAC2 overexpression has opposing effects
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270727 Mus musculus Embryonic Stem Cell
pmid sentence
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270750 Homo sapiens
pmid sentence
The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. 
Publications: 1 Organism: Homo Sapiens
Tissue: Substantia Nigra
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268627 Homo sapiens
pmid sentence
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270621 Homo sapiens
pmid sentence
The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. 
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-268626 Homo sapiens
pmid sentence
Polycomb group (PcG) and Trithorax group (TrxG) proteins are epigenetic regulators that control gene expression through modulating chromatin structure and addition of posttranslational modifications (PTMs) on histones
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270759 Homo sapiens
pmid sentence
The BAF (mammalian SWI/SNF) complexes are a family of multi-subunit ATP-dependent chromatin remodelers that use ATP hydrolysis to alter chromatin structure. Distinct BAF complex compositions are possible through combinatorial assembly of homologous subunit families and can serve non-redundant functions. In mammalian neural development, developmental stage-specific BAF assemblies are found in embryonic stem cells, neural progenitors and postmitotic neurons. In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as well as long-term memory formation. 
Publications: 1 Organism: Homo Sapiens
Tissue: Substantia Nigra
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-270609 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Epigenetic_regulation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269828 Homo sapiens
pmid sentence
Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodelers that modulate genomic architecture and DNA accessibility, enabling timely and appropriate control of gene expression. They are combinatorially assembled from the products of 29 total genes into three final-form complexes: canonical BAF, PBAF (polybromo-associated BAF complexes), and a newly-defined non-canonical BAF (ncBAF), with specific subunits specifying distinct complexes, such as PBRM1, ARID2, and BRD7 in PBAF complexes, ARID1A/ARID1B and DPF2 in canonical BAF (cBAF) complexes, and GLTSCR1/GLTSCR1L and BRD9 in ncBAF complexes
Publications: 1 Organism: Homo Sapiens
a simple tooltip