| + |
D1-D2-G-X3 complex | up-regulates activity 
|
CHEK2 |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263262 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23438602 |
Interestingly, as with ATM (40, 41), XRCC3-deficient cells exhibited RDS and impaired CHK2 activation|Notably, early activation of CHK2 in S/G2 phase was downstream of XRCC3 recruitment as well as its phosphorylation at the sites of DSBs. NBS1 also has been shown to be involved in the early activation of CHK2 in response to IR (42). It is likely that NBS1-dependent CHK2 phosphorylation is mediated through XRCC3 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCG | form complex 
binding
|
D1-D2-G-X3 complex |
0.728 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263254 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18212739 |
These results argue that FANCG has a role independent of the FA core complex, and we propose that phosphorylation of serine 7 is the signalling event required for forming a discrete complex comprising FANCD1/BRCA2-FANCD2-FANCG-XRCC3 (D1-D2-G-X3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XRCC3 | form complex
binding
|
D1-D2-G-X3 complex |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18212739 |
These results argue that FANCG has a role independent of the FA core complex, and we propose that phosphorylation of serine 7 is the signalling event required for forming a discrete complex comprising FANCD1/BRCA2-FANCD2-FANCG-XRCC3 (D1-D2-G-X3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRCA2 | form complex
binding
|
D1-D2-G-X3 complex |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263256 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18212739 |
These results argue that FANCG has a role independent of the FA core complex, and we propose that phosphorylation of serine 7 is the signalling event required for forming a discrete complex comprising FANCD1/BRCA2-FANCD2-FANCG-XRCC3 (D1-D2-G-X3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D1-D2-G-X3 complex | up-regulates activity 
relocalization
|
RAD51 |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23438602 |
We examined the effect of XRCC3 depletion on redistribution of RAD51 upon IR damage|Interestingly, cells expressing the XRCC3 S225A phosphomutant showed compromised chromatin loading of RAD51 upon IR damage (Fig. 4G) while the nuclear and cytosolic fractions of RAD51 were largely unchanged|It is likely that BRCA2 may directly participate in RAD51 recruitment and XRCC3 may stabilize the RAD51 filament which is in part mediated by phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FANCD2 | form complex
binding
|
D1-D2-G-X3 complex |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263255 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18212739 |
These results argue that FANCG has a role independent of the FA core complex, and we propose that phosphorylation of serine 7 is the signalling event required for forming a discrete complex comprising FANCD1/BRCA2-FANCD2-FANCG-XRCC3 (D1-D2-G-X3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
D1-D2-G-X3 complex