Summary

Name FANCD2
Full Name Fanconi anemia group D2 protein
Synonyms Protein FACD2 | FACD
Primary ID Q9BXW9
Links - -
Type protein
Relations 20
Function Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FANCD2 0.783
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FANCD2 0.61
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FANCD2 0.658
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding, relocalization BRCA2 0.807
Publications: 2 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Fanconi anemia ID complex 0.956
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination FANCD2 0.897
Publications: 2 Organism: Homo Sapiens,
+ up-regulates activity img/direct-activation.png ubiquitination FANCD2 0.698
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination FANCD2 0.764
Publications: 2 Organism: , Homo Sapiens
+ up-regulates img/direct-activation.png binding FANCD2 0.455
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deubiquitination FANCD2 0.753
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding D1-D2-G-X3 complex 0.736
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination FANCD2 0.839
Publications: 1 Organism: Homo Sapiens