| + |
Complement C1 complex | up-regulates activity 
cleavage
|
C2 |
0.474 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263418 |
Arg243 |
KTKESLGrKIQIQRS |
|
|
| pmid |
sentence |
| 31331124 |
C1s subsequently activate serum proteins C4 and C2. C4 is cleaved to fragment C4a, which is an anaphylatoxin, and to fragment C4b, which is deposited on the adjacent surfaces. C2 is cleaved to a fragment C2b, and larger fragment C2a, which binds noncovalently to C4b on the target cell membrane. This forms the C4b2a complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263421 |
Ser20 |
LYPGLADsAPSCPQN |
|
|
| pmid |
sentence |
| 31331124 |
C1s subsequently activate serum proteins C4 and C2. C4 is cleaved to fragment C4a, which is an anaphylatoxin, and to fragment C4b, which is deposited on the adjacent surfaces. C2 is cleaved to a fragment C2b, and larger fragment C2a, which binds noncovalently to C4b on the target cell membrane. This forms the C4b2a complex |
|
| Publications: |
2 |
| Pathways: | Complement Signaling |
| + |
Complement C1 complex | up-regulates activity
cleavage
|
C4A |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263433 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263436 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263439 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
| + |
Complement C1 complex | up-regulates activity
cleavage
|
C4B |
0.631 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263424 |
Arg679 |
EKTTRKKrNVNFQKA |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263427 |
Arg756 |
KGQAGLQrALEILQE |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263430 |
Gly1446 |
TPLQLFEgRRNRRRR |
in vitro |
|
| pmid |
sentence |
| 9087411 |
The classical complement activation pathway, like the MELinitiated pathway, involves the generation of a C3-converting complex, C4b2b, through enzymatic activation of C4 and C2. In the C1 complex (C1qr2s2), this specific protease activity is exhibited by C1s after activation of this enzyme by C1r. When C4 is activated, its reactive thiol ester is exposed and C4b binds covalently to nearby amino or hydroxyl groups. The C4-activating abilities of MASP-1 and MASP-2 were compared.|Activation of C4 by Ct sand MASP-2 on western blots. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
C1S | form complex 
binding
|
Complement C1 complex |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263394 |
|
|
in vitro |
|
| pmid |
sentence |
| 29449492 |
The complement system is part of our innate immune system. The classical complement pathway is triggered by activation of the C1 initiation complex upon binding to cell surfaces. C1, or C1qr2s2, consists of four proteases, C1r and C1s, that associate with C1q, which contains antibody-binding sites.|The reconstruction reveals densities for all C1q collagen-like triple helices and gC1q modules, C1r and C1s proteases |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
C1R | form complex
binding
|
Complement C1 complex |
0.684 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263395 |
|
|
in vitro |
|
| pmid |
sentence |
| 29449492 |
The complement system is part of our innate immune system. The classical complement pathway is triggered by activation of the C1 initiation complex upon binding to cell surfaces. C1, or C1qr2s2, consists of four proteases, C1r and C1s, that associate with C1q, which contains antibody-binding sites.|The reconstruction reveals densities for all C1q collagen-like triple helices and gC1q modules, C1r and C1s proteases |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Complement C1q | form complex
binding
|
Complement C1 complex |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263396 |
|
|
in vitro |
|
| pmid |
sentence |
| 29449492 |
The complement system is part of our innate immune system. The classical complement pathway is triggered by activation of the C1 initiation complex upon binding to cell surfaces. C1, or C1qr2s2, consists of four proteases, C1r and C1s, that associate with C1q, which contains antibody-binding sites.|The reconstruction reveals densities for all C1q collagen-like triple helices and gC1q modules, C1r and C1s proteases |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Complement Signaling |
3.0
Complement C1 complex
CPX-1920