+ |
C3 convertase complex | up-regulates activity
cleavage
|
C3 |
0.54 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263449 |
Arg671 |
QPAARRRrSVQLTEK |
|
|
pmid |
sentence |
31331124 |
This forms the C4b2a complex, which is a classical pathway C3 convertase. C4b2a cleaves C3, which is the central component of the complement cascade, to C3a, and anaphylatoxin, and C3b results in the activation of the lytic pathway |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263450 |
Arg748 |
ASHLGLArSNLDEDI |
|
|
pmid |
sentence |
31331124 |
This forms the C4b2a complex, which is a classical pathway C3 convertase. C4b2a cleaves C3, which is the central component of the complement cascade, to C3a, and anaphylatoxin, and C3b results in the activation of the lytic pathway |
|
Publications: |
2 |
Pathways: | Complement Signaling |
+ |
C2 | form complex
binding
|
C3 convertase complex |
0.627 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263399 |
|
|
in vitro |
|
pmid |
sentence |
17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
Publications: |
1 |
Organism: |
In Vitro |
Pathways: | Complement Signaling |
+ |
C3 convertase complex | form complex
binding
|
C5 convertase complex |
0.525 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263447 |
|
|
|
|
pmid |
sentence |
31331124 |
C3b associates with C3 convertase to form C5 convertase and cleaves C5. |
|
Publications: |
1 |
Pathways: | Complement Signaling |
+ |
C4A | form complex
binding
|
C3 convertase complex |
0.607 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263400 |
|
|
in vitro |
|
pmid |
sentence |
17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
Publications: |
1 |
Organism: |
In Vitro |
Pathways: | Complement Signaling |
+ |
C4B | form complex
binding
|
C3 convertase complex |
0.655 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263398 |
|
|
in vitro |
|
pmid |
sentence |
17204478 |
However, following cleavage of C4, C2 binds tightly to C4b to form the C4b2 complex |
|
Publications: |
1 |
Organism: |
In Vitro |