| + |
MSL acetyltransferase | down-regulates activity 
acetylation
|
H4C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263944 |
Lys17 |
GLGKGGAkRHRKVLR |
Homo sapiens |
|
| pmid |
sentence |
| 16227571 |
We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271984 |
Lys35 |
RKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC20P |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271988 |
Lys35 |
KKRKRSRkESYSIYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC12 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271979 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271994 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC17 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271982 |
Lys35 |
KKRKRSRkESYSIYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC18 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271987 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271985 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BW2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271981 |
Lys35 |
ANSTKAQkQKRRGCR |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271986 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271983 |
Lys35 |
KKRKRSRkESYSIYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC15 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271993 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BU1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271990 |
Lys35 |
KKRKRGRkESYSIYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271995 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271980 |
Lys35 |
KKRKRSRkESYSIYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271991 |
Lys35 |
KKRKRSRkESYSVYV |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271992 |
Lys36 |
KKRKRTRkESYSIYI |
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL2 | form complex 
binding
|
MSL acetyltransferase |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263941 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16227571 |
We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HeLa Cell |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
H2BW1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271989 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL acetyltransferase | down-regulates activity
monoubiquitination
|
Histone H2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271978 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21726816 |
MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34ub, in turn, promotes H2B K120ub, H3 K4me3 and K79me2 to facilitate transcription elongation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSL1 | form complex
binding
|
MSL acetyltransferase |
0.847 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263942 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16227571 |
We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HeLa Cell |
| + |
MSL3 | form complex
binding
|
MSL acetyltransferase |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263940 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16227571 |
We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HeLa Cell |
| + |
KAT8 | form complex
binding
|
MSL acetyltransferase |
0.801 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263943 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16227571 |
We describe a stable, multisubunit human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
HeLa Cell |
3.0
MSL acetyltransferase
CPX-815