Relation Results

Summary

Name Class I MHC:Antigen
Primary ID SIGNOR-C426
Type complex
Formed by Class I MHC, peptide antigen
Relations 6
Pathways Mitochondrial dynamics in T cell exhaustion, T cell activation

Viewer

Type: Score: Layout: SPV 
0.70.70.20.20.80.2Class I MHC:AntigenCytotoxic_T-lymphocyte_activationT_cell_activationTCRCD8Apeptide antigenClass I MHC

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ Class I MHC:Antigenup-regulates img/indirect-activation.png Cytotoxic_T-lymphocyte_activation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267875 Homo sapiens
pmid sentence
High-affinity peptide/MHC class I complexes that successfully pass the aforementioned “quality controls” will be transported through the Golgi apparatus to the cell membrane to elicit antigen-specific CD8+ T cell responses.
Publications: 1 Organism: Homo Sapiens
+ Class I MHC:Antigenup-regulates img/indirect-activation.png T_cell_activation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267775 Homo sapiens
pmid sentence
High-affinity peptide/MHC class I complexes that successfully pass the aforementioned “quality controls” will be transported through the Golgi apparatus to the cell membrane to elicit antigen-specific CD8+ T cell responses.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ Class I MHC:Antigenup-regulates activity img/direct-activation.png binding TCR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267993 Homo sapiens
pmid sentence
The interaction of T-cell receptors (TCRs) with self- and non-self-peptides in the major histocompatibility complex (MHC) stimulates crucial signaling events, which in turn can activate T lymphocytes.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ Class I MHC:Antigenup-regulates activity img/direct-activation.png binding CD8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267991 Homo sapiens
pmid sentence
Molecular recognition of pMHCI complexes is mediated primarily by clonally distributed TCRs expressed on the surface of CTLs. The coreceptor CD8 contributes to this antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling, the effects of which serve to enhance TCR stimuli triggered by cognate ligands.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ peptide antigenform complex img/form-complex.png binding Class I MHC:Antigen 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267773 Homo sapiens
pmid sentence
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR).
Publications: 1 Organism: Homo Sapiens
+ Class I MHCform complex img/form-complex.png binding Class I MHC:Antigen 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267774 Homo sapiens
pmid sentence
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR).
Publications: 1 Organism: Homo Sapiens
a simple tooltip