| + |
Class I MHC | form complex 
binding
|
Class I MHC:Antigen |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267774 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
peptide antigen | form complex
binding
|
Class I MHC:Antigen |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33374673 |
The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Class I MHC:Antigen | up-regulates activity 
binding
|
CD8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21954283 |
Molecular recognition of pMHCI complexes is mediated primarily by clonally distributed TCRs expressed on the surface of CTLs. The coreceptor CD8 contributes to this antigen-recognition process by binding to a largely invariant region of the MHCI molecule and by promoting intracellular signaling, the effects of which serve to enhance TCR stimuli triggered by cognate ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
Class I MHC:Antigen | up-regulates activity
binding
|
TCR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267993 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31001252 |
The interaction of T-cell receptors (TCRs) with self- and non-self-peptides in the major histocompatibility complex (MHC) stimulates crucial signaling events, which in turn can activate T lymphocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
Class I MHC:Antigen | up-regulates 
|
Cytotoxic_T-lymphocyte_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267875 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
High-affinity peptide/MHC class I complexes that successfully pass the aforementioned “quality controls” will be transported through the Golgi apparatus to the cell membrane to elicit antigen-specific CD8+ T cell responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Class I MHC:Antigen | up-regulates
|
T_cell_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267775 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31810556 |
High-affinity peptide/MHC class I complexes that successfully pass the aforementioned “quality controls” will be transported through the Golgi apparatus to the cell membrane to elicit antigen-specific CD8+ T cell responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
3.0
Class I MHC:Antigen