| + |
MTERF4 | form complex 
binding
|
MTERF4-NSUN4 mitochondiral ribosomal assembly complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22949673 |
We recently showed that a member of the mitochondrial transcription termination factor (MTERF) family of proteins, MTERF4, recruits NSUN4, a 5-methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitochondrial ribosome biogenesis. Here, we describe the 3D crystal structure of the human MTERF4-NSUN4 complex determined to 2.9 Å resolution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NSUN4 | form complex
binding
|
MTERF4-NSUN4 mitochondiral ribosomal assembly complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280901 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22949673 |
We recently showed that a member of the mitochondrial transcription termination factor (MTERF) family of proteins, MTERF4, recruits NSUN4, a 5-methylcytosine RNA methyltransferase, to the large ribosomal subunit in a process crucial for mitochondrial ribosome biogenesis. Here, we describe the 3D crystal structure of the human MTERF4-NSUN4 complex determined to 2.9 Å resolution. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTERF4-NSUN4 mitochondiral ribosomal assembly complex | up-regulates 
|
Ribosome biogenesis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280902 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15701510 |
The nicotinic ACh receptor is a member of the pentameric “Cys-loop” superfamily of transmitter-gated ion channels, which includes neuronal ACh receptors, GABAA receptors, 5-HT3 receptors and glycine receptors.1, 2, 3, 4, 5 The channel is found in high concentrations at the nerve–muscle synapse, where it mediates fast chemical transmission of electrical signals in response to ACh released from the nerve terminal into the synaptic cleft. It is a large (290 kDa) glyco-protein, assembled from a ring of homologous subunits (α, γ, α, β, δ) and divided into three domains |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
4.0
MTERF4-NSUN4 mitochondiral ribosomal assembly complex
CPX-885