| + |
Rix1 complex | up-regulates 
|
Ribosome biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265473 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22190736 |
In this study, we show that LAS1L forms a protein complex with PELP1, TEX10, NOL9, SENP3, and WDR18. Our data demonstrate that all the components of the LAS1L complex cosediment with the pre-60S ribosomal particle and are required for proper processing of the 32S rRNA intermediate.These findings demonstrate that the LAS1L complex is critical for ribosome biogenesis and cell proliferation and provide additional evidence that multiple protein complexes have distinct functions in the synthesis of eukaryotic ribosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIN4 | up-regulates
|
Ribosome biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265754 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12860119 |
Par14 is a pre-rRNA processing factor involved in mammalian ribosome biogenesis, Par14 deficiency slowed cell growth (Fig. 3A) and reduced the production of 18 and 28 S rRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6 | up-regulates
|
Ribosome biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264619 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23318442 |
Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264617 |
|
|
in vitro |
|
| pmid |
sentence |
| 19812304 |
The stimulation of S6K1 activity by mTORC1 leads to increases in mRNA biogenesis, cap-dependent translation and elongation, and the translation of ribosomal proteins through regulation of the activity of many proteins, such as S6K1 aly/REF-like target (SKAR), programmed cell death 4 (PDCD4), eukaryotic elongation factor 2 kinase (eEF2K) and ribosomal protein S6 |
|
| Publications: |
2 |
Organism: |
Mus Musculus, In Vitro |
3.0
Ribosome biogenesis