| + |
TIM8B-TIM13 mitochondrial intermembrane space protein transporter complex | up-regulates activity 
binding
|
Cytochrome c oxidase-Mitochondrial respiratory chain complex IV |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37272231 |
We demonstrate that hTim8a and hTim8b function in the assembly of cytochrome c oxidase (Complex IV). Using affinity enrichment mass spectrometry, we define the interaction network of hTim8a, hTim8b and hTim13, identifying subunits and assembly factors of the Complex IV COX2 module. These data suggest that hTim8a and hTim8b function in assembly of Complex IV via interactions with intermediate-assembly subcomplexes. We propose that hTim8-hTim13 complexes are auxiliary assembly factors involved in the formation of the Complex IV S3 subcomplex during assembly of mature Complex IV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIMM8B | form complex 
binding
|
TIM8B-TIM13 mitochondrial intermembrane space protein transporter complex |
0.883 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281389 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37272231 |
We demonstrate that hTim8a and hTim8b function in the assembly of cytochrome c oxidase (Complex IV). Using affinity enrichment mass spectrometry, we define the interaction network of hTim8a, hTim8b and hTim13, identifying subunits and assembly factors of the Complex IV COX2 module. These data suggest that hTim8a and hTim8b function in assembly of Complex IV via interactions with intermediate-assembly subcomplexes. We propose that hTim8-hTim13 complexes are auxiliary assembly factors involved in the formation of the Complex IV S3 subcomplex during assembly of mature Complex IV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TIMM13 | form complex
binding
|
TIM8B-TIM13 mitochondrial intermembrane space protein transporter complex |
0.883 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37272231 |
We demonstrate that hTim8a and hTim8b function in the assembly of cytochrome c oxidase (Complex IV). Using affinity enrichment mass spectrometry, we define the interaction network of hTim8a, hTim8b and hTim13, identifying subunits and assembly factors of the Complex IV COX2 module. These data suggest that hTim8a and hTim8b function in assembly of Complex IV via interactions with intermediate-assembly subcomplexes. We propose that hTim8-hTim13 complexes are auxiliary assembly factors involved in the formation of the Complex IV S3 subcomplex during assembly of mature Complex IV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
TIM8B-TIM13 mitochondrial intermembrane space protein transporter complex