| + |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase | down-regulates quantity 
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281394 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
3-Ketoacyl-acyl carrier protein (ACP) reductase (KAR) catalyses the second step of the mtFAS pathway (Fig. 1). Although all the other mtFAS enzymes identified thus far are encoded by single genes, human KAR (HsKAR) is a heterotetrametric α2β2 enzyme formed by two subunits, 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase | up-regulates quantity 
chemical modification
|
NADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
3-Ketoacyl-acyl carrier protein (ACP) reductase (KAR) catalyses the second step of the mtFAS pathway (Fig. 1). Although all the other mtFAS enzymes identified thus far are encoded by single genes, human KAR (HsKAR) is a heterotetrametric α2β2 enzyme formed by two subunits, 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBR4 | form complex 
binding
|
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
The human 3-ketoacyl-acyl carrier protein (ACP) reductase (KAR) of mtFAS is a heterotetrameric α2β2-assembly composed of 17β-hydroxysteroid dehydrogenase type-8 (HSD17B8, α-subunit) and carbonyl reductase type-4 (CBR4, β-subunit). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HSD17B8 | form complex
binding
|
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281392 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
The human 3-ketoacyl-acyl carrier protein (ACP) reductase (KAR) of mtFAS is a heterotetrameric α2β2-assembly composed of 17β-hydroxysteroid dehydrogenase type-8 (HSD17B8, α-subunit) and carbonyl reductase type-4 (CBR4, β-subunit). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase | down-regulates quantity
chemical modification
|
O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281393 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
3-Ketoacyl-acyl carrier protein (ACP) reductase (KAR) catalyses the second step of the mtFAS pathway (Fig. 1). Although all the other mtFAS enzymes identified thus far are encoded by single genes, human KAR (HsKAR) is a heterotetrametric α2β2 enzyme formed by two subunits, 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase | up-regulates quantity
chemical modification
|
O-(S-3-oxoacylpantetheine-4'-phosphoryl)-L-serine(1-) residue |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281395 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25203508 |
3-Ketoacyl-acyl carrier protein (ACP) reductase (KAR) catalyses the second step of the mtFAS pathway (Fig. 1). Although all the other mtFAS enzymes identified thus far are encoded by single genes, human KAR (HsKAR) is a heterotetrametric α2β2 enzyme formed by two subunits, 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase