| + |
CSNK2A1 | down-regulates activity
phosphorylation
|
PIN4 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265753 |
Ser19 |
AGKGGAAsGSDSADK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12860119 |
As proved by MALDI-TOF mass spectrometry and MS/MS fragmentation, hPar14 is phosphorylated at Ser19 in vitro and in vivo. In human HeLa cells the protein is most likely modified by casein kinase 2 (CK2). |In contrast to wild-type hPar14, the in vitro DNA-binding affinity of the Glu19 mutant is strongly reduced, suggesting that only the dephosphorylated protein is the active DNA-binding form of hPar14 in the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIN4 | up-regulates
|
Ribosome biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265754 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12860119 |
Par14 is a pre-rRNA processing factor involved in mammalian ribosome biogenesis, Par14 deficiency slowed cell growth (Fig. 3A) and reduced the production of 18 and 28 S rRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIN4 | up-regulates
|
rRNA_transcription |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265755 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12860119 |
Par14 is a pre-rRNA processing factor involved in mammalian ribosome biogenesis, Par14 deficiency slowed cell growth (Fig. 3A) and reduced the production of 18 and 28 S rRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIN4 | up-regulates activity
isomerization
|
IRS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265756 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 23720771 |
In this study, the association of Par14 with insulin receptor substrate 1 (IRS-1) was demonstrated in HepG2 cells|Therefore, although Pin1 and Par14 associate with different portions of IRS-1, the prolyl cis/trans isomerization in multiple sites of IRS-1 by these isomerases appears to be critical for efficient insulin receptor-induced IRS-1 phosphorylation|Par14 overexpression in HepG2 markedly enhanced insulin-induced IRS-1 phosphorylation and its downstream events |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |