| + |
2-oxoglutarate(2-) | up-regulates 
|
Citric_Acid_Cycle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267821 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
A branch-point metabolite α-ketoglutarate is generated in the TCA cycle during the oxidation of carbohydrates and fatty acids and by glutamate dehydrogenase during the oxidative deamination of glutamate. The enzymes that form the mitochondrial α-ketoglutarate– dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme system of the tricarboxylic acid cycle, might mediate the interaction of these processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Aspartate and asparagine metabolism, Glutamine metabolism |
| + |
Citric_Acid_Cycle | up-regulates 
|
succinate(2-) |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280301 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28185716 |
CII (SDH) comprises four subunits (SDHA, SDHB, SDHC, and SDHD) encoded by nuclear DNA (nDNA). In additional to its role in OXPHOS, SDH is a component of the TCA cycle, making a functional link between these two essential processes [2–6]. In the TCA cycle, SDH oxidizes succinate to fumarate [3,7]. As part of OXPHOS, SDH transfers electrons from succinate via its [Fe–S] clusters to ubiquinone (UbQ) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
fumarate(2-) | up-regulates
|
Citric_Acid_Cycle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267989 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30090811 |
Fumarase is a TCA cycle enzyme which catalyzes the conversion of fumarate to L-malate in the mitochondria. Upon DNA damage the cytosolic echoform of fumarase is localized to the nucleus, there, its enzymatic activity catalyzes the reverse conversion of malate to fumarate, so causing local accumulation of fumarate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
pyruvate | up-regulates activity
|
Citric_Acid_Cycle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267384 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18613815 |
Pyruvate carboxylase (PC) is a biotin-containing enzyme that catalyses the HCO3−- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. This is a very important anaplerotic reaction, replenishing oxaloacetate withdrawn from the Krebs cycle for various pivotal biochemical pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis, Glycolysis and Gluconeogenesis |
4.0
Citric_Acid_Cycle