| + |
DAMPS | up-regulates activity 
|
NLRP1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256421 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
DAMPS | up-regulates
|
AP-3/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAMPS | up-regulates activity
|
NAIP |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256420 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
DAMPS | up-regulates activity 
binding
|
TLRs |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25644504 |
The innate immune system is present in almost all multicellular organisms and its activation occurs in response to pathogens or tissue injury via pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response, Inflammosome Activation, Toll like receptors |
| + |
DAMPS | up-regulates
|
AP-2/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DAMPS | up-regulates activity
|
AIM2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256419 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
DAMPS | up-regulates activity
|
MEFV |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256422 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
DAMPS | up-regulates
|
AP-1/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267854 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DAMPS