Relation Results

Summary

Name Viral_dsRNA
Primary ID SIGNOR-ST21
Type stimulus
Description
Relations 7
Pathways COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.7Viral_replicationViral_dsRNAPOLR3AIFIH1DDX58G3BP1DDX1EIF2AK2

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Relations
Regulator
Mechanism
target
score ℹ
+ Viral_replicationup-regulates img/indirect-activation.png Viral_dsRNA 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260587 Homo sapiens
pmid sentence
Double-stranded RNA (dsRNA), a common intermediate during the replication of DNA and RNA viruses.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA
+ POLR3Aup-regulates img/direct-activation.png Viral_dsRNA 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265563 Homo sapiens
pmid sentence
Here we show that the cytosolic poly(dA-dT) DNA is converted into 5′-ppp RNA to induce IFN-β through the RIG-I pathway. Biochemical purification led to the identification of DNA-dependent RNA polymerase III (Pol-III) as the enzyme responsible for synthesizing 5′-ppp RNA from the poly(dA-dT) template. Inhibition of RNA Pol-III prevents IFN-β induction by transfection of DNA or infection with DNA viruses.
Publications: 1 Organism: Homo Sapiens
+ Viral_dsRNAup-regulates img/direct-activation.png IFIH1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260142 Homo sapiens
pmid sentence
Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ Viral_dsRNAup-regulates img/direct-activation.png DDX58 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260141 Homo sapiens
pmid sentence
Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial membrane protein MAVS, which in turn activates the kinases TBK1 and IKKɛ.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, SARS-CoV STRESS GRANULES
+ Viral_dsRNAup-regulates activity img/direct-activation.png binding G3BP1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260979
pmid sentence
The RGG domain of G3BP1 could mediate the direct binding of HCV-dsRNA and poly(IC)
Publications: 1
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV STRESS GRANULES
+ Viral_dsRNAup-regulates img/indirect-activation.png DDX1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260190 Mus musculus
pmid sentence
We demonstrated here that DDX1-DDX21-DHX36 represents a dsRNA sensor that uses the adaptor molecule TRIF to activate the NF-κB pathway and type I IFN responses in dendritic cells. Our study suggests that the DDX1-DDX21-DHX36 complex represents this missing poly I:C sensor, which uses DDX1 to bind poly I:C and uses DDX21 and DXH36 to bind TRIF. Poly I:C is a synthetic form of RNA that mimics double-stranded viral RNA.
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA
+ Viral_dsRNAup-regulates img/indirect-activation.png EIF2AK2 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-260167 Homo sapiens
pmid sentence
PKR is an interferon-stimulated gene (ISG) activated by binding of double-stranded RNA (dsRNA), a common intermediate during the replication of DNA and RNA viruses.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV STRESS GRANULES, SARS-CoV ER STRESS
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