| + |
hsa-miR-21-5p | down-regulates quantity by repression 
post transcriptional regulation
|
CCL20 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278006 |
|
|
Homo sapiens |
SiHa Cell |
| pmid |
sentence |
| 22001440 |
MiR-21 may suppress gene expression through miR-21-binding sequences at the 3′-UTR of CCL20 gene . This suggests that miR-21 represses CCL20 expression by targeting the 3′UTR. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278005 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 22099878 |
As miR-21 regulates the expression of a luciferase construct which contains the 30UTR of CCL20 mRNA, we suggest that miR-21 regulates CCL20 gene expression by a regulatory element present in the 3UTR of CCL20 mRNA. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
dehydroepiandrosterone | up-regulates quantity by expression 
post transcriptional regulation
|
hsa-miR-21-5p |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279813 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25969534 |
Together, these data suggest that the rapid DHEA-induced increase in pri-miR-21 and miR-21 is a transcriptional response that requires GPCR signaling, EGFR activation, Src kinase activity, intact PM structure, and MAPK and PI3K activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPER1 | up-regulates activity
post transcriptional regulation
|
hsa-miR-21-5p |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279814 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 25969534 |
MiR-21 transcription is regulated by DHEA through GPER. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-21-5p | down-regulates quantity by repression
post transcriptional regulation
|
TGFBR2 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279892 |
|
|
Homo sapiens |
Adipose-derived Stem Cell |
| pmid |
sentence |
| 19816956 |
Overexpression of miR-21 reduced both protein and mRNA levels of TGFBR2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-21-5p | down-regulates quantity by repression
post transcriptional regulation
|
PTEN |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282560 |
|
|
Homo sapiens |
SK-HEP-1 Cell |
| pmid |
sentence |
| 17681183 |
An increase in relative luciferase activity was noted with anti–miR-21 in all HCC cells, indicating that miR-21 can modulate gene expression directly at the PTEN 3′-UTR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-21-5p | down-regulates quantity by destabilization
post transcriptional regulation
|
NTF3 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279949 |
|
|
Homo sapiens |
CaSki Cell |
| pmid |
sentence |
| 39828780 |
The dual luciferase reporter assay confirmed that NTF3 is a direct target of miR-21. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
hsa-miR-21-5p
