4.0
IBD_DENDRITIC CELLS
Pathway ID: SIGNOR-CROHN_DENDR
Description: Main pathways activated in the Dendritic Cell during Inflammatory Bowel diseases (IBD), which include Crohn's disease and Ulcerative Colitis. During IBDs, the activation of signaling pathways such as NF-κB, MAPK, PI3K/Akt/mTOR, and autophagy processes promotes the production of pro-inflammatory cytokines and modulates inflammation, proliferation, and apoptosis. These pathways also promote the activation and maturation of effector T cells, contributing to the persistence of the immune response in the intestinal mucosa.
Curated by: Tiberia
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Description: Main pathways activated in the Dendritic Cell during Inflammatory Bowel diseases (IBD), which include Crohn's disease and Ulcerative Colitis. During IBDs, the activation of signaling pathways such as NF-κB, MAPK, PI3K/Akt/mTOR, and autophagy processes promotes the production of pro-inflammatory cytokines and modulates inflammation, proliferation, and apoptosis. These pathways also promote the activation and maturation of effector T cells, contributing to the persistence of the immune response in the intestinal mucosa.
Curated by: Tiberia
Use SIGNOR Cytoscape App
81 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| hsa-miR-150-5p | URS000016FD1A_9606 |
| M1_polarization | SIGNOR-PH54 |
| JUN | P05412 |
| miR-155 | URS000062749E_9606 |
| hsa-miR-146a | URS00005E1F00_9606 |
| hsa-miR-143-3p | URS00005C2A6D_9606 |
| MYD88 | Q99836 |
| IKBKG | Q9Y6K9 |
| IRAK1 | P51617 |
| Class II MHC:Antigen | SIGNOR-C429 |
| LUBAC | SIGNOR-C527 |
| ATG16L1 | Q676U5 |
| JNK | SIGNOR-PF15 |
| TRAF6 | Q9Y4K3 |
| ITCH | Q96J02 |
| SLC15A1 | P46059 |
| XIAP | P98170 |
| PKA | SIGNOR-PF17 |
| Autophagosome_formation | SIGNOR-PH36 |
| RPS6KA5 | O75582 |
| peptide antigen | CHEBI:166824 |
| nitric oxide | CHEBI:16480 |
| TICAM1 | Q8IUC6 |
| PI3K | SIGNOR-C156 |
| hsa-mir-98-5p | URS00004E0808_9606 |
| mTORC2 | SIGNOR-C2 |
| IRF4 | Q15306 |
| MAP2K6 | P52564 |
| ATG12/5/16L1 | SIGNOR-C109 |
| CCL2 | P13500 |
| IKBKB | O14920 |
| NFKB1 | P19838 |
| PELI3 | Q8N2H9 |
| muramyl dipeptide | CHEBI:59414 |
| BIRC3 | Q13489 |
| CREB1 | P16220 |
| TIRAP | P58753 |
| FOXO | SIGNOR-PF27 |
| MAP3K7 | O43318 |
| NFKBIA | P25963 |
| TLR2 | O60603 |
| GPCR | SIGNOR-PF33 |
| TAB2 | Q9NYJ8 |
| TBK1 | Q9UHD2 |
| TNF | P01375 |
| NOD2 | Q9HC29 |
| MAP2K3 | P46734 |
| IKK-complex | SIGNOR-C14 |
| CHUK | O15111 |
| Survival | SIGNOR-PH13 |
| IL1B | P01584 |
| PIP3 | CHEBI:16618 |
| p38 | SIGNOR-PF16 |
| mTORC1 | SIGNOR-C3 |
| MAP2K7 | O14733 |
| NfKb-p65/p50 | SIGNOR-C13 |
| TLR4 | O00206 |
| Apoptosis | SIGNOR-PH2 |
| MAP2K4 | P45985 |
| Proliferation | SIGNOR-PH4 |
| NLRP3 inflammasome | SIGNOR-C225 |
| Immune_response | SIGNOR-PH17 |
| NOS2 | P35228 |
| Inflammation | SIGNOR-PH12 |
| RIPK2 | O43353 |
| MAPK14 | Q16539 |
| IL6 | P05231 |
| hsa-mir-146a-5p | URS000050B527_9606 |
| MAPK8 | P45983 |
| hsamir7085p | URS000019D79B_9606 |
| TICAM2 | Q86XR7 |
| hsa-mir-149-5p | URS00001C770D_9606 |
| GSK3B | P49841 |
| TAB1 | Q15750 |
| Helper_T-lymphocyte_activation | SIGNOR-PH196 |
| ATG16L1 | Q676U5-2 |
| GNB/GNG | SIGNOR-C202 |
| TP53 | P04637 |
| AKT | SIGNOR-PF24 |
| SLC15A4 | Q8N697 |
| hsa-mir-186-5p | URS000040DCFF_9606 |