3.0
Macrophage: TNF alpha transcriptional regulation
Pathway ID: SIGNOR-MacroTNFATR
Description: The recruitment of macrophages in the early stage of muscle regeneration process provides the right pro-inflammatory environment, allowing debris clearance and good sources of pro-inflammatory cytokines that satellite cells use to initiate their proliferation program. These cytokines include TNF alpha produced by macrophages, whose gene is transcriptionally regulated by IRF5 transcription factor. The switch toward an anti-inflammatory macrophage phenotype is guaranteed through several mechanisms, including a cooperation between STAT6 transcription factor and KLF4, that cooperate to inhibit TNF alpha gene expression.
Curated by: Alessandro Palma
Description: The recruitment of macrophages in the early stage of muscle regeneration process provides the right pro-inflammatory environment, allowing debris clearance and good sources of pro-inflammatory cytokines that satellite cells use to initiate their proliferation program. These cytokines include TNF alpha produced by macrophages, whose gene is transcriptionally regulated by IRF5 transcription factor. The switch toward an anti-inflammatory macrophage phenotype is guaranteed through several mechanisms, including a cooperation between STAT6 transcription factor and KLF4, that cooperate to inhibit TNF alpha gene expression.
Curated by: Alessandro Palma
5 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| A9/b1 integrin | SIGNOR-C166 |
| TNF | P01375 |
| IRF5 | Q13568 |
| KLF4 | O43474 |
| STAT6 | P42226 |