| + |
CBLB | down-regulates quantity 
ubiquitination
|
STAT6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278805 |
Lys108 |
QILQGEKkAVMEQFR |
Homo sapiens |
|
| pmid |
sentence |
| 24508458 |
Having shown that Cbl-b negatively regulates Stat6, we further investigated the mechanism of this regulation by determining whether Cbl-b associates with Stat6.|Our data demonstrate that Stat6 is ubiquitinated at K108 and K398 by Cbl-b, and that Stat6 ubiquitination is a critical post-translational regulatory mechanism for Stat6. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278806 |
Lys398 |
SFTLGPGkLPIQLQA |
Homo sapiens |
|
| pmid |
sentence |
| 24508458 |
Having shown that Cbl-b negatively regulates Stat6, we further investigated the mechanism of this regulation by determining whether Cbl-b associates with Stat6.|Our data demonstrate that Stat6 is ubiquitinated at K108 and K398 by Cbl-b, and that Stat6 ubiquitination is a critical post-translational regulatory mechanism for Stat6. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TBK1 | up-regulates 
phosphorylation
|
STAT6 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176771 |
Ser407 |
PIQLQALsLPLVVIV |
Homo sapiens |
|
| pmid |
sentence |
| 22000020 |
We now show that stat6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger sting (also named mita/eris) to recruit stat6 to the endoplasmic reticulum, leading to stat6 phosphorylation on ser(407) by tbk1 and tyr(641), independent of jaks. Phosphorylated stat6 then dimerizes and translocates to the nucleus to induce specific target genes responsible for immune cell homing. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176775 |
Tyr641 |
MGKDGRGyVPATIKM |
Homo sapiens |
|
| pmid |
sentence |
| 22000020 |
We now show that stat6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger sting (also named mita/eris) to recruit stat6 to the endoplasmic reticulum, leading to stat6 phosphorylation on ser(407) by tbk1 and tyr(641), independent of jaks. Phosphorylated stat6 then dimerizes and translocates to the nucleus to induce specific target genes responsible for immune cell homing. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | down-regulates
phosphorylation
|
STAT6 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170153 |
Ser707 |
IPPYQGLsPEESVNV |
Homo sapiens |
|
| pmid |
sentence |
| 21123173 |
Deactivation of stat6 through serine 707 phosphorylation by jnk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
STAT6 | down-regulates activity
binding
|
NfKb-p65/p50 |
0.416 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249553 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 10982806 |
STAT6 mediates suppression of STAT1 and NF-kB-dependent transcription by distinct mechanisms. Both processes are dependent upon the STAT6 transactivation domain and may involve sequestration of necessary but different transcriptional coactivator proteins. These two suppressive mechanisms are controlled differentially by the nature of the STAT6 DNA-binding site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
SND1 | up-regulates activity
binding
|
STAT6 |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259134 |
|
|
in vitro |
|
| pmid |
sentence |
| 12234934 |
STAT6 interacted with p100 in vitro and in vivo. Here, we show that the TAD of STAT6 is interacting with p100. p100 was found to enhance the STAT6-mediated transcription [.]. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
STAT6 | up-regulates 
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249541 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22025054 |
IL-4R signals through a JAKSTAT6 pathway, and many of the genes associated with mouse M2 macrophages are regulated by STAT6, including arginase 1 (Arg1), macrophage mannose receptor 1 (Mrc1; also known as Cd206), resistin-like-? (Retnla; also known as Fizz1) and chitinase 3-like 3 (Chi3l3; also known as Ym1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
STAT6 | down-regulates activity
binding
|
STAT1 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249552 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 10982806 |
STAT6 mediates suppression of STAT1 and NF-kB-dependent transcription by distinct mechanisms. Both processes are dependent upon the STAT6 transactivation domain and may involve sequestration of necessary but different transcriptional coactivator proteins. These two suppressive mechanisms are controlled differentially by the nature of the STAT6 DNA-binding site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
SOCS1 |
0.642 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17093501 |
We found that IL-4, like IFN-gamma, induces rapid de novo expression of SOCS-1 in primary macrophages. Induction of SOCS-1 gene expression by IL-4 is STAT6-dependent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
JAK2 | up-regulates activity
phosphorylation
|
STAT6 |
0.676 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9852261 |
Stat6 activation is mediated through jak1 and jak2 tyrosine kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249532 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 18852293 |
Downstream intracellular signaling from the IL-4IL-4Rc complex involves activation of the Jak1 and Jak3 kinases, phosphorylation of the Stat6 transcription factor, and activation of the insulin receptor substrate (IRS)-2 and Dok2-signaling intermediates. IL-13 initially binds to IL-13R1 with intermediate affinity, and then heterodimerizes with IL-4R. The IL-13IL-13R1IL-4R complex activates the Tyk2, Jak2, and Jak1 kinases and Stat6. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25934862 |
IL-4-induced macrophage polarization involves induction of STAT6 and KLF4 that induce each other and promote M2 polarization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
CHI3L1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249537 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
RETN |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249536 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | down-regulates activity 
|
PPARG |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254682 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24948596 |
IL-4 was shown to inhibit lipid accumulation in adipose tissue by a mechanism that includes activation of Stat6, which suppresses PPARα transcriptional activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Macrophage polarization |
| + |
STAT6 | up-regulates
|
ALOX15 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254101 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 12517954 |
IL-4 has been shown to up-regulate 15-lipoxygenase and produce 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in A549 cells via the Janus kinase/STAT6 pathway under coactivation of CREB binding protein/p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
PPARA |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249534 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
HSD3B2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255249 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15632317 |
IL-4 induces HSD3B1 gene expression, along with IL-13, through STAT 6 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
KLF4 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
STAT6 coordinates and synergizes with both PPAR? and Krppel-like factor 4 (KLF4), a member of a family of proteins that contribute to macrophage function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN2 | down-regulates activity
dephosphorylation
|
STAT6 |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235192 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17210636 |
These results identify TCPTP as a physiological regulator of STAT6 phosphorylation and suggest that specific increases in TCPTP expression in ABC-like DLBCLs may contribute to the different biological characteristics of these tumors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
STAT6 |
0.768 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9852261 |
Stat6 activation is mediated through jak1 and jak2 tyrosine kinases |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249531 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 23124025 |
IL-4-stimulated Stat6 activation is mediated by Jak1 whereas Tyk2 is required for Stat6 activation in IL-13-treated monocytes |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates
|
STAT6 |
0.618 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62578 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 9852037 |
Expression of an shp-1 transgene in nih 3t3 cells markedly reduces both il-4-dependent stat6 activation and stat6-mediated transcription of il-4-responsive genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249533 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
SLC26A4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255250 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24429829 |
We then examined the ability of STAT6 to bind each of the N4 GAS motifs in vivo with a site-specific ChIP assay, the results of which showed that STAT6 interacted with only the N4 GAS motif that was functionally implicated in increasing the activity of the pendrin promoter following IL-4 treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
KDM6B |
0.438 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19567879 |
We demonstrate that IL-4dependent Jmjd3 expression is mediated by STAT6, a major transcription factor of IL-4mediated signaling. After IL-4 stimulation, activated STAT6 is increased and binds to consensus sites at the Jmjd3 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
KLF4 | up-regulates
|
STAT6 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249569 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22378047 |
KLF4 cooperates with Stat6 to induce M2 genes (Arg-1, Mrc1, Fizz1, PPAR?) and inhibit M1 genes (TNFa, Cox-2, CCL5, iNOS) via sequestration of coactivators required for NF-kappaB activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN1 | down-regulates activity
dephosphorylation
|
STAT6 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22156494 |
Phosphorylated STAT6 may also serve as a cytoplasmic substrate for PTP1B since overexpression of PTP1B leads to STAT6 dephosphorylation and the suppression of STAT6 transcriptional activity, whereas PTP1B deficiency increases IL-4-induced STAT6 signaling in B-cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
MRC1 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates
|
GATA3 |
0.669 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254299 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12947222 |
GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT6 | up-regulates
|
ARG1 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255557 |
|
|
|
Macrophage |
| pmid |
sentence |
| 25386178 |
Cytokines like IL-4 or IL-13 lead to STAT6 phosphorylation with consecutive arginase expression and varying further aspects of M2 polarization (mannose receptor, Ym1, Fizz1) |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
4.0
STAT6
- 
- 