Summary

Name ELOVL7
Full Name Elongation of very long chain fatty acids protein 7
Synonyms 3-keto acyl-CoA synthase ELOVL7, ELOVL fatty acid elongase 7, ELOVL FA elongase 7, Very long chain 3-ketoacyl-CoA synthase 7, Very long chain 3-oxoacyl-CoA synthase 7 |
Primary ID A1L3X0
Links - -
Type protein
Relations 2
Function Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification 3-hydroxyoctadecanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification palmitoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens