| + |
ELOVL | down-regulates quantity 
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267901 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ACSL1 | up-regulates quantity 
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267877 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21242590 |
Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. On the other hand, overexpression of ACSL1 resulted in large increases in oleoyl-CoA synthesis and palmitoyl-CoA synthesis in SMC lysates (Fig. 4A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ELOVL5 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267891 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
palmitoyl-CoA | up-regulates quantity
precursor of
|
3-hydroxyoctadecanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267881 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267884 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267883 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267880 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267885 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267879 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267900 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
8 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ELOVL7 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267888 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL1 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL3 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL6 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL4 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267892 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ELOVL2 | down-regulates quantity
chemical modification
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31616255 |
The ELOVL family of enzymes in mammals is comprised of seven members that all reside in the endoplasmic reticulum (ER) and are thought to form a multimeric complex. Together, the ELOVL family is responsible for the elongation of saturated and unsaturated fatty acids.Fatty acid elongation occurs by cycling through a four step process (condensation, reduction, dehydration, and reduction), with two carbon atoms added through each cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hexadecanoic acid | up-regulates quantity
precursor of
|
palmitoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267876 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21242590 |
Long-chain acyl-CoA synthetases (ACSLs) catalyze the thioesterification of long-chain FAs into their acyl-CoA derivatives. On the other hand, overexpression of ACSL1 resulted in large increases in oleoyl-CoA synthesis and palmitoyl-CoA synthesis in SMC lysates (Fig. 4A). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
3.0
palmitoyl-CoA