Summary

Name MACROD2
Full Name ADP-ribose glycohydrolase MACROD2
Synonyms MACRO domain-containing protein 2, [Protein ADP-ribosylglutamate] hydrolase | C20orf133
Primary ID A1Z1Q3
Links - -
Type protein
Relations 3
Function Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746).

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Relations

Regulator Mechanism target score ℹ
+ MACROD2up-regulates quantity img/direct-activation.png chemical modification acetate 0.8
Publications: 1 Organism: Homo Sapiens
+ MACROD2up-regulates quantity img/direct-activation.png chemical modification ADP-D-ribose(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ MACROD2down-regulates quantity img/direct_inhibition.png chemical modification 2''-O-acetyl-ADP-D-ribose(2-) 0.8
Publications: 1 Organism: Homo Sapiens