3.0
Summary
| Name |  CNOT1
|
| Full Name | CCR4-NOT transcription complex subunit 1 |
| Synonyms | CCR4-associated factor 1, Negative regulator of transcription subunit 1 homolog, NOT1H, hNOT1 | CDC39, KIAA1007, NOT1 |
| Primary ID | A5YKK6 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CNOT1 | form complex 
binding
|
CCR4-NOT complex | 0.89 |
| Publications: | 1 | Organism: | Homo Sapiens | |