| + |
TOB2 | down-regulates activity 
binding
|
CCR4-NOT complex |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273615 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18377426 |
We found that Tob associates with the CCR4-NOT complex. The carboxyl-terminal half of Tob interacted with Cnot1, a core protein of the CCR4-NOT complex. We further showed that the deadenylase activity associated with the complex was suppressed in vitro by Tob. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by destabilization
chemical modification
|
messenger RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268312 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression principally via shortening of poly(A) tails of messenger RNA or deadenylation. |The poly(A) tails at 3′ ends of eukaryotic mRNAs are crucial for their cytoplasmic stability and to enhance the initiation of translation. Newly synthesized metazoan mRNAs possess long poly(A) tails1, and following export to the cytoplasm the tails are reported to be ~60–80 nucleotides on average at steady state2. Poly(A) tails are also important for translational efficiency at the embryonic stage2 and the length of the poly(A) tail was reported to be correlated with translational efficiency3. The multisubunit CCR4-NOT complex is principally responsible for efficient processive shortening of poly(A) tails, or deadenylation, in addition to other function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | mRNA maturation, mRNA maturation |
| + |
CNOT2 | form complex 
binding
|
CCR4-NOT complex |
0.826 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TOB1 | down-regulates activity
binding
|
CCR4-NOT complex |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273616 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18377426 |
We found that Tob associates with the CCR4-NOT complex. The carboxyl-terminal half of Tob interacted with Cnot1, a core protein of the CCR4-NOT complex. We further showed that the deadenylase activity associated with the complex was suppressed in vitro by Tob. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT7 | form complex
binding
|
CCR4-NOT complex |
0.831 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT6L | form complex
binding
|
CCR4-NOT complex |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268311 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
PUM1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268351 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
RC3H1 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
NANOS1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268346 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT6 | form complex
binding
|
CCR4-NOT complex |
0.813 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268309 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
NANOS3 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT9 | form complex
binding
|
CCR4-NOT complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
PUM2 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
NANOS2 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT8 | form complex
binding
|
CCR4-NOT complex |
0.789 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268310 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT4 | form complex
binding
|
CCR4-NOT complex |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNKS1BP1 | form complex
binding
|
CCR4-NOT complex |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268304 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT3 | form complex
binding
|
CCR4-NOT complex |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268301 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT10 | form complex
binding
|
CCR4-NOT complex |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268305 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT11 | form complex
binding
|
CCR4-NOT complex |
0.818 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR4-NOT complex | down-regulates quantity by repression
post transcriptional regulation
|
RC3H2 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268353 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31320642 |
In addition to its role in bulk mRNA decay, CCR4-NOT can also catalyze the deadenylation or promote translational repression of specific mRNA targets to which it is recruited by RNA binding proteins, such as Nanos, Roquin and Puf/Pumilio proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNOT1 | form complex
binding
|
CCR4-NOT complex |
0.892 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19558367 |
In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CCR4-NOT complex
CPX-707