| + |
ECHS1 | down-regulates quantity 
chemical modification
|
trans-dec-2-enoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280366 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40804397 |
The ECHS1 (short-chain enoyl-CoA hydratase 1) gene is critical for mitochondrial fatty acid β-oxidation and branched-chain amino acid metabolism. In particular, enzymatic assays and molecular characterization from the late 20th to early 21st century confirmed that ECHS1 catalyzes the hydration of short-chain enoyl-CoA, a key step in mitochondrial β-oxidation, essential for metabolic stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
trans-dec-2-enoyl-CoA | up-regulates quantity 
precursor of
|
(S)-3-hydroxydecanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40804397 |
The ECHS1 (short-chain enoyl-CoA hydratase 1) gene is critical for mitochondrial fatty acid β-oxidation and branched-chain amino acid metabolism. In particular, enzymatic assays and molecular characterization from the late 20th to early 21st century confirmed that ECHS1 catalyzes the hydration of short-chain enoyl-CoA, a key step in mitochondrial β-oxidation, essential for metabolic stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACADM | up-regulates quantity
chemical modification
|
trans-dec-2-enoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280359 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3035565 |
Medium-chain acyl-CoA dehydrogenase (MCAD; acyl-CoA: (acceptor) 2,3- oxidoreductase, EC 1.3.99.3) is one of three similar enzymes that catalyze the initial step of fatty acid beta-oxidation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
decanoyl-CoA | up-regulates quantity
precursor of
|
trans-dec-2-enoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3035565 |
Medium-chain acyl-CoA dehydrogenase (MCAD; acyl-CoA: (acceptor) 2,3- oxidoreductase, EC 1.3.99.3) is one of three similar enzymes that catalyze the initial step of fatty acid beta-oxidation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECR | down-regulates quantity
chemical modification
|
trans-dec-2-enoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18479707 |
The mitochondrial FAS II pathway includes a 2-enoyl thioester reductase (ETR1), also known as MECR. This enzyme (MECR/ETR1, EC 1.3.1.38) catalyzes in the fatty acid elongation cycle in the last step, which is the NADPH-dependent reduction of the Cα–Cβ double bond of the enoyl–ACP substrate molecule (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
trans-dec-2-enoyl-CoA | up-regulates quantity
precursor of
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18479707 |
The mitochondrial FAS II pathway includes a 2-enoyl thioester reductase (ETR1), also known as MECR. This enzyme (MECR/ETR1, EC 1.3.1.38) catalyzes in the fatty acid elongation cycle in the last step, which is the NADPH-dependent reduction of the Cα–Cβ double bond of the enoyl–ACP substrate molecule (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
trans-dec-2-enoyl-CoA