Summary

Name ACADM
Full Name Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Synonyms MCAD |
Primary ID P11310
Links - -
Type protein
Relations 8
Pathways Fatty Acid Beta-Oxidation
Function Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:25416781, PubMed:15159392). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268).

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Relations

Regulator Mechanism target score ℹ
+ ACADMup-regulates quantity img/direct-activation.png chemical modification trans-oct-2-enoyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADMdown-regulates quantity img/direct_inhibition.png chemical modification decanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ PPARGdown-regulates activity img/direct_inhibition.png binding ACADM 0.346
Publications: 1 Organism: Homo Sapiens
+ ACADMdown-regulates quantity img/direct_inhibition.png chemical modification FAD(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADMup-regulates quantity img/direct-activation.png chemical modification FADH2(2-) 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADMup-regulates quantity img/direct-activation.png chemical modification trans-dec-2-enoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADMdown-regulates quantity img/direct_inhibition.png chemical modification octanoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
+ ACADMup-regulates img/indirect-activation.png Fatty_acid_oxidation 0.7
Publications: 1 Organism: Homo Sapiens