Relation Results

Summary

Name choline
Synonyms Bilineurine (KEGG COMPOUND), Choline (KEGG COMPOUND), choline (UniProt), CHOLINE ION (PDBeChem), N,N,N-trimethylethanol-ammonium (ChEBI), N-trimethylethanolamine (ChEBI), trimethylethanolamine (ChEBI)
IUPAC 2-hydroxy-N,N,N-trimethylethanaminium
Formula C5H14NO
Primary ID CHEBI:15354
Type small molecule
Relations 4

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Type: Score: Layout: SPV 
0.80.80.80.8CHKBcholineCHKAcholine phosphate(1-)SLC44A2

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Relations
Regulator
Mechanism
target
score ℹ
+ CHKBdown-regulates quantity img/direct_inhibition.png chemical modification choline 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-275635
pmid sentence
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes
Publications: 1
+ CHKAdown-regulates quantity img/direct_inhibition.png chemical modification choline 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-275637
pmid sentence
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes
Publications: 1
+ cholineup-regulates quantity img/direct-activation.png precursor of choline phosphate(1-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-275633
pmid sentence
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes
Publications: 1
+ SLC44A2up-regulates activity img/direct-activation.png relocalization choline 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-260409 Homo sapiens
pmid sentence
Among these, SLC44A2 (a putative choline transporter) was strikingly upregulated by ethanol (three fold), and GCN5 silencing downregulated it
Publications: 1 Organism: Homo Sapiens
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