| + |
PKA | up-regulates activity 
phosphorylation
|
CHKB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275632 |
Ser39 |
TPKRRRAsSLSRDAE |
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. | This study provides evidence for CKβ phosphorylation by protein kinase A (PKA).|Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mutagenesis. Phosphorylation increased the catalytic efficiencies for the substrates choline and ATP about 2-fold, without affecting ethanolamine phosphorylation, and the S39D/S40D CKβ phosphorylation mimic behaved kinetically very similar. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275631 |
Ser40 |
PKRRRASsLSRDAER |
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. | This study provides evidence for CKβ phosphorylation by protein kinase A (PKA).|Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mutagenesis. Phosphorylation increased the catalytic efficiencies for the substrates choline and ATP about 2-fold, without affecting ethanolamine phosphorylation, and the S39D/S40D CKβ phosphorylation mimic behaved kinetically very similar. |
|
| Publications: |
2 |
| + |
PRKACA | up-regulates activity
phosphorylation
|
CHKB |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275630 |
Ser39 |
TPKRRRAsSLSRDAE |
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. | This study provides evidence for CKβ phosphorylation by protein kinase A (PKA).|Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mutagenesis. Phosphorylation increased the catalytic efficiencies for the substrates choline and ATP about 2-fold, without affecting ethanolamine phosphorylation, and the S39D/S40D CKβ phosphorylation mimic behaved kinetically very similar. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275629 |
Ser40 |
PKRRRASsLSRDAER |
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase beta (CKbeta) is one of the CK isozymes involved in the biosynthesis of phosphatidylcholine. | This study provides evidence for CKβ phosphorylation by protein kinase A (PKA).|Phosphorylation sites were located on CKβ residues serine-39 and serine-40 as determined by mass spectrometry and site-directed mutagenesis. Phosphorylation increased the catalytic efficiencies for the substrates choline and ATP about 2-fold, without affecting ethanolamine phosphorylation, and the S39D/S40D CKβ phosphorylation mimic behaved kinetically very similar. |
|
| Publications: |
2 |
| + |
CHKB | up-regulates quantity
chemical modification
|
choline phosphate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275634 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
| + |
CHKB | up-regulates quantity
chemical modification
|
O-phosphonatoethanaminium(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275639 |
|
|
|
|
| pmid |
sentence |
| 29928787 |
In this study, we investigated the roles of ethanolamine kinases (Etnk-1 and 2) and choline kinases (Chk-α and β) in contributing to increased PE in human breast and pancreatic cancer cells. |
|
| Publications: |
1 |
| + |
CHKB | down-regulates quantity 
chemical modification
|
choline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275635 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
| + |
CHKB | down-regulates quantity
chemical modification
|
ethanolaminium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275640 |
|
|
|
|
| pmid |
sentence |
| 29928787 |
In this study, we investigated the roles of ethanolamine kinases (Etnk-1 and 2) and choline kinases (Chk-α and β) in contributing to increased PE in human breast and pancreatic cancer cells. |
|
| Publications: |
1 |
3.0
CHKB
- 
- 