| + |
KAT5 | up-regulates activity 
acetylation
|
CHKA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267648 |
Lys247 |
MPFNKEPkWLFGTME |
Homo sapiens |
|
| pmid |
sentence |
| 34929314 |
Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | up-regulates activity
phosphorylation
|
CHKA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267647 |
Ser279 |
KKLHKLLsYNLPLEL |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
Glucose deprivation induces the binding of choline kinase α2 (CHKα2) to lipid droplets, followed by a continuous PTMs to promote lipolysis of lipid droplets, which are in turn mediated by AMPK-dependent CHKα2 Serine 279 phosphorylation and KAT5-dependent CHKα2 Lysine 247 acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization 
phosphorylation
|
DEPTOR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279604 |
Ser286 |
SSMSSCGsSGYFSSS |
Homo sapiens |
|
| pmid |
sentence |
| 22017875 |
DEPTOR phosphorylation by mTOR in response to growth signals, and in collaboration with casein kinase I (CKI), generates a phosphodegron that binds βTrCP.|These data suggests that CKI overexpression may overcome a requirement for phosphorylation at the major mTOR sites in DEPTOR for formation of the degron and are consistent with our finding that CKI can phosphorylate S286 and S287 in DEPTOR in vitro in the absence of mTOR. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279605 |
Ser287 |
SMSSCGSsGYFSSSP |
Homo sapiens |
|
| pmid |
sentence |
| 22017875 |
These data suggests that CKI overexpression may overcome a requirement for phosphorylation at the major mTOR sites in DEPTOR for formation of the degron and are consistent with our finding that CKI can phosphorylate S286 and S287 in DEPTOR in vitro in the absence of mTOR. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
CHKA |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266351 |
Tyr197 |
RSLGPKLyGIFPQGR |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266350 |
Tyr333 |
LMLIDFEySSYNYRG |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
PLIN2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267649 |
Tyr232 |
TKLHSRAyQQALSRV |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
In addition, as a protein kinase, CHKalpha2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
PLIN3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267650 |
Tyr251 |
ERLRQHAyEHSLGKL |
Homo sapiens |
Glioblastoma Cell |
| pmid |
sentence |
| 34929314 |
In addition, as a protein kinase, CHKα2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates activity
phosphorylation
|
SRC |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279731 |
Tyr530 |
FTSTEPQyQPGENL |
Homo sapiens |
|
| pmid |
sentence |
| 28784162 |
Figure XREF_FIG shows that even though Chk phosphorylated Tyr 527 of Src to a level much lower than that of Csk, it was a much more efficient inhibitor of Src kinase activity.|These results suggest that Chk inhibited Src with a mechanism independent of Tyr-527 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | up-regulates quantity
chemical modification
|
choline phosphate(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275636 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
KDR |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22711876 |
Here, we show for the first time a possible mechanism by which CKI dependent phosphorylation of VEGFR2 at specific sites in its C-terminal tail triggers SCF beta-TRCP -mediated VEGFR2 ubiquitination and destruction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
MDM2 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20708156 |
The data presented here provides evidence for a molecular mechanism by which CKI-dependent phosphorylation of Mdm2 at multiple sites triggers SCF \u03b2-TRCP -mediated Mdm2 destruction ( xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | up-regulates activity
binding
|
EGFR |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266352 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21822308 |
We find that CHKA forms a complex with EGFR in a c-Src-dependent manner. Endogenous CHKA and EGFR co-immunoprecipitated from a variety of breast cancer cell lines and immortalized mammary epithelial cells. CHKA interacted with the EGFR kinase domain upon c-Src co-overexpression and was phosphorylated in a c-Src-dependent manner on Y197 and Y333. CHKA is required for maximum EGF-dependent cell growth in mammary epithelium-derived cell lines |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity
chemical modification
|
choline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275637 |
|
|
|
|
| pmid |
sentence |
| 27149373 |
Choline kinase (CK) phosphorylates choline in the cytidine diphosphate (CDP)-choline pathway for the biosynthesis of phosphatidylcholine (PC), the most abundant class of phospholipids in eukaryotic membranes |
|
| Publications: |
1 |
| + |
ATR | up-regulates activity
phosphorylation
|
CHKA |
0.247 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280184 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16085356 |
In particular, ATR phosphorylates Chk 1 and ATM signals to Chk 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | up-regulates activity
phosphorylation
|
TUT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21729869 |
Our data indicate that the kinase activities of both the isoforms of CKI -- alpha and epsilon modulate Star-PAP polyadenylation activity and target mRNAs.|Taken together, these data suggest that phosphorylation of Star-PAP by CKI modulates the Star-PAP polyadenylation activity downstream of stimulation by oxidant stress and phosphorylation primes Star-PAP, so that it can be stimulated by PI4,5 P 2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates activity
phosphorylation
|
VANGL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31090542 |
CKI\u03b5-dependent phosphorylation increases Stbm turnover at junctions, and thus promotes complex sorting, while phosphorylation of Dsh decreases its turnover.|Interestingly, CKI\u03b5 has been implicated in phosphorylation of both Stbm and Dsh. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates activity
phosphorylation
|
CTNNB1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279161 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11818547 |
The data suggest that CKI phosphorylates and destabilizes the beta-catenin degradation complex, likely through the dissociation of PP2A, providing a mechanism by which CKI stabilizes beta-catenin and propagates the Wnt signal. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates activity
phosphorylation
|
LPIN1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28049764 |
Because CKI is a constitutively active kinase and ubiquitously distributed in many cell types, high mTORC1 activity depending on nutritional status may be a physiological cue for Lipin1 degradation mediated by CKI and beta-TRCP.|Thus, we propose that mTORC1 may function as a priming kinase for CKI to promote the phosphorylation of the degron motif in Lipin1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
NCOA3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280229 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21577200 |
First, by using purified recombinant SRC-3 (XREF_FIG) and CKI proteins, we found that CKI is able to phosphorylate SRC-3 (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CHKA
- 
- 