| + |
TK2 | down-regulates quantity 
chemical modification
|
2'-deoxyuridine |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25215937 |
Thymidine kinase 2 (TK2, EC 27.1.21) catalyzes the transfer of the γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine (dT), deoxycytidine (dC), or deoxyuridine (dU) to form their corresponding monophosphates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2'-deoxyuridine | up-regulates quantity 
precursor of
|
dUMP(2-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25215937 |
Thymidine kinase 2 (TK2, EC 27.1.21) catalyzes the transfer of the γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine (dT), deoxycytidine (dC), or deoxyuridine (dU) to form their corresponding monophosphates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UPP1 | up-regulates quantity
chemical modification
|
2'-deoxyuridine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
uracil | up-regulates quantity
precursor of
|
2'-deoxyuridine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280540 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
UPP2 | up-regulates quantity
chemical modification
|
2'-deoxyuridine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21855639 |
Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in activating fluoropyrimidine nucleoside chemotherapeutic agents such as 5-fluorouracil and capecitabine. Most vertebrate animals, including humans, possess two homologs of this enzyme (UPP1 & UPP2), of which UPP1 has been more thoroughly studied and is better characterized |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
2'-deoxyuridine