| + |
ACADM | down-regulates quantity 
chemical modification
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3035565 |
Medium-chain acyl-CoA dehydrogenase (MCAD; acyl-CoA: (acceptor) 2,3- oxidoreductase, EC 1.3.99.3) is one of three similar enzymes that catalyze the initial step of fatty acid beta-oxidation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Trifunctional enzyme | up-regulates quantity 
chemical modification
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280354 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29551309 |
The second step in the β-oxidation of fatty acids is the hydration of the trans-double bond to generate a 3-l-hydroxyacyl-coA ester, catalyzed by enoyl-coA hydratase. In the third step, 3-l-hydroxyacyl-coA dehydrogenase catalyzes the oxidation of the 3-l-hydroxyacyl-coA ester to a 3-ketoacyl-coA intermediate while NADH is generated from NAD+. The fourth and final step is the thiolytic cleavage of the chain by a ketothiolase, generating acetyl-coA and a fatty-acyl-coA two carbon atoms shorter. This shortened acyl-coA ester may start again the oxidation cycle. (Fig. 3) In humans, a single enzyme catalyzes the three last steps in the β-oxidation of long-chain fatty acids, the mitochondrial trifunctional protein (MTP) complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-oxolauroyl-CoA | up-regulates quantity
precursor of
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29551309 |
The second step in the β-oxidation of fatty acids is the hydration of the trans-double bond to generate a 3-l-hydroxyacyl-coA ester, catalyzed by enoyl-coA hydratase. In the third step, 3-l-hydroxyacyl-coA dehydrogenase catalyzes the oxidation of the 3-l-hydroxyacyl-coA ester to a 3-ketoacyl-coA intermediate while NADH is generated from NAD+. The fourth and final step is the thiolytic cleavage of the chain by a ketothiolase, generating acetyl-coA and a fatty-acyl-coA two carbon atoms shorter. This shortened acyl-coA ester may start again the oxidation cycle. (Fig. 3) In humans, a single enzyme catalyzes the three last steps in the β-oxidation of long-chain fatty acids, the mitochondrial trifunctional protein (MTP) complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
decanoyl-CoA | up-regulates quantity
precursor of
|
trans-dec-2-enoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280360 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3035565 |
Medium-chain acyl-CoA dehydrogenase (MCAD; acyl-CoA: (acceptor) 2,3- oxidoreductase, EC 1.3.99.3) is one of three similar enzymes that catalyze the initial step of fatty acid beta-oxidation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECR | up-regulates quantity
chemical modification
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18479707 |
The mitochondrial FAS II pathway includes a 2-enoyl thioester reductase (ETR1), also known as MECR. This enzyme (MECR/ETR1, EC 1.3.1.38) catalyzes in the fatty acid elongation cycle in the last step, which is the NADPH-dependent reduction of the Cα–Cβ double bond of the enoyl–ACP substrate molecule (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
trans-dec-2-enoyl-CoA | up-regulates quantity
precursor of
|
decanoyl-CoA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280365 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18479707 |
The mitochondrial FAS II pathway includes a 2-enoyl thioester reductase (ETR1), also known as MECR. This enzyme (MECR/ETR1, EC 1.3.1.38) catalyzes in the fatty acid elongation cycle in the last step, which is the NADPH-dependent reduction of the Cα–Cβ double bond of the enoyl–ACP substrate molecule (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
decanoyl-CoA