+ |
bisphenol A | down-regulates activity
chemical inhibition
|
TPO |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268786 |
|
|
in vitro |
|
pmid |
sentence |
17379648 |
Half-maximal inhibition of TPO by BPA and F21388 occurred at 174 and 37.5 mol/liter in the guaiacol assay. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
bisphenol A | up-regulates activity
chemical activation
|
AHR |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268735 |
|
|
in vitro |
|
pmid |
sentence |
31995776 |
This study investigated the endocrine-disrupting activity of BPA, BPF, and BPS alone or as a mixture and the agonistic and antagonistic activity of the BPs using an in vitro bioassay to detect ER-, AR-, and AhR-mediated activity.In our study, BPs showed AhR agonist activity only at the highest concentrations, and the mixture did not differ from the single BPs. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
bisphenol A | up-regulates activity
chemical activation
|
ESR1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268729 |
|
|
in vitro |
|
pmid |
sentence |
31995776 |
This study investigated the endocrine-disrupting activity of BPA, BPF, and BPS alone or as a mixture and the agonistic and antagonistic activity of the BPs using an in vitro bioassay to detect ER-, AR-, and AhR-mediated activity. Here, we evaluated the endocrine-disrupting risks of the bisphenols by investigating their agonist and antagonist activities with the estrogen (ER), androgen (AR), and aryl hydrocarbon (AhR) receptors. Our results showed that BPA, BPS, and BPF (BPs) have estrogen agonist and androgen antagonist activities and decrease the ERα protein level. . |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268738 |
|
|
in vitro |
|
pmid |
sentence |
9751507 |
Bisphenol A is an equally strong agonist for ERα as for ERβ, and the same is true for 4,4′-biphenol, which differs from bisphenol A in that it lacks the propane group between the phenolic rings. |
|
Publications: |
2 |
Organism: |
In Vitro |
+ |
bisphenol A | up-regulates activity
chemical activation
|
ESR2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268739 |
|
|
in vitro |
|
pmid |
sentence |
9751507 |
Bisphenol A is an equally strong agonist for ERα as for ERβ, and the same is true for 4,4′-biphenol, which differs from bisphenol A in that it lacks the propane group between the phenolic rings. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
bisphenol A | down-regulates activity
chemical inhibition
|
AR |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268732 |
|
|
in vitro |
|
pmid |
sentence |
31995776 |
This study investigated the endocrine-disrupting activity of BPA, BPF, and BPS alone or as a mixture and the agonistic and antagonistic activity of the BPs using an in vitro bioassay to detect ER-, AR-, and AhR-mediated activity. Here, we evaluated the endocrine-disrupting risks of the bisphenols by investigating their agonist and antagonist activities with the estrogen (ER), androgen (AR), and aryl hydrocarbon (AhR) receptors. Our results showed that BPA, BPS, and BPF (BPs) have estrogen agonist and androgen antagonist activities and decrease the ERα protein level. . |
|
Publications: |
1 |
Organism: |
In Vitro |