Summary

Name ESR2
Full Name Estrogen receptor beta
Synonyms ER-beta, Nuclear receptor subfamily 3 group A member 2 | ESTRB, NR3A2
Primary ID Q92731
Links - -
Type protein
Relations 28
Pathways Oxytocin signaling
Inhibitors afimoxifene; tamoxifen citrate; tamoxifen; fulvestrant
Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN10A 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ up-regulates img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CRH 0.401
Publications: 1 Organism: Homo Sapiens
Tissue: Hypothalamus
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN9A 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN1A 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN1A 0.298
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ESR2 0.605
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TFF1 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN11A 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png chemical inhibition ESR2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFA 0.264
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation ESR2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding ESR2 0.5
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling