| + |
OSBPL9-OSBPL10 oxysterol-binding protein-related complex | up-regulates quantity 
relocalization
|
phosphatidylinositol 4-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281506 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36853333 |
We showed that the PH domains of ORP9 and ORP10 could interact with PI4P on the TGN, providing the membrane tethering to target TGN. This reconstitution system demonstrated that the ORP9-ORP10 complex efficiently transfers PI4P/PS between the apposed membranes. Previous studies showed that ORP10 maintains the ER-TGN MCSs integrity with the requirement of PS transfer from the ER to the TGN. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
phosphatidylinositol 4-phosphate | up-regulates 
|
Receptor_mediated_ endocytosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260745 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 22253445 |
Further research suggested that PI4P plays an essential role in SARS-CoV spike-mediated entry, which is regulated by the PI4P lipid microenvironment. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
phosphatidylinositol 4-phosphate | up-regulates activity
binding
|
DOP1A-MON2, golgi-endosome traffic complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281442 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31324770 |
Here, we find that Dopey1 and Mon2 assemble into a complex and localize to the Golgi, endolysosome and endoplasmic reticulum exit site. The Golgi localization of Dopey1 and Mon2 requires their binding to phosphatidylinositol-4-phosphate and phosphatidic acid, respectively, two lipids known for the biogenesis of membrane carriers and the specification of organelle identities. The N-terminus of Dopey1 further interacts with kinesin-1, a plus-end or centrifugal-direction microtubule motor. Dopey1-Mon2 complex functions as a dual-lipid-regulated cargo-adaptor to recruit kinesin-1 to secretory and endocytic organelles or membrane carriers for centrifugally biased bidirectional transport. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SACM1L | down-regulates quantity 
chemical modification
|
phosphatidylinositol 4-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260733 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 22253445 |
To investigate whether kinase activity could account for the different effects of the PI kinases on SARS-CoV S-mediated entry and to test whether PI4P lipids directly regulate viral entry independent of PI4KB, VeroE6 cells were transiently transfected with the SAC1 gene, a PI phosphatase that specifically converts PI4P lipids back to PI (27).|These results indicate that PI4P is indispensable for SARS-CoV S-mediated entry and suggest that PI4KB mediates SARS-CoV S entry by regulating the level of cellular PI4P. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
| + |
PI4KB | up-regulates quantity
chemical modification
|
phosphatidylinositol 4-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260732 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 22253445 |
Interestingly, we found that PI4P, the product of PI4KB catalysis, creates a lipid microenvironment that is required for SARS-CoV S-mediated entry. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
4.0
phosphatidylinositol 4-phosphate