Summary
Name | SACM1L |
Full Name | Phosphatidylinositol-3-phosphatase SAC1 |
Synonyms | Suppressor of actin mutations 1-like protein | KIAA0851 |
Primary ID | Q9NTJ5 |
Links | - - |
Type | protein |
Relations | 2 |
Pathways | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |
Function | Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:29461204, PubMed:24209621, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099). |
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Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | SACM1L | down-regulates | Receptor_mediated_ endocytosis | 0.7 |
Publications: | 1 | Organism: | Chlorocebus Aethiops | |
Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY | |||
+ | SACM1L | down-regulates quantity chemical modification | phosphatidylinositol 4-phosphate | 0.8 |
Publications: | 1 | Organism: | Chlorocebus Aethiops | |
Pathways: | COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY |