| + |
NADP(3-) | up-regulates quantity 
precursor of
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34775382 |
6 PG undergoes oxidative decarboxylation by 6-phosphogluconate dehydrogenase (6PGD) producing Ru5P and the second NADPH molecule. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33064660 |
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ME2 | up-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267054 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
MECR | down-regulates quantity 
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280362 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18479707 |
The mitochondrial FAS II pathway includes a 2-enoyl thioester reductase (ETR1), also known as MECR. This enzyme (MECR/ETR1, EC 1.3.1.38) catalyzes in the fatty acid elongation cycle in the last step, which is the NADPH-dependent reduction of the Cα–Cβ double bond of the enoyl–ACP substrate molecule (Fig. 1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NADPH(4-) | up-regulates activity
binding
|
FASN |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267371 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34765544 |
We determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ME1 | up-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267055 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis, Pentose phosphate pathway |
| + |
G6PD | up-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267052 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
NADPH(4-) | down-regulates activity
binding
|
PGD |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267372 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34765544 |
We determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH. PGDH is the onl yrate-limiting unidirectional enzyme susceptible to allosteric inhibition by NADPH |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
GMPR | down-regulates quantity
chemical modification
|
NADPH(4-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280510 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33369428 |
The human GMPR enzyme maintains the intracellular balance between the adenine and guanine nucleotide pools. The chemical reaction of this enzyme proceeds by deamination and hydride transfer steps. In deamination, the thiol group of Cys186 reacts on C2 of 5GP to form an intermediate E-XMP. In the second step, nicotinamide moves adjacent to C2 of E-XMP to allow hydride ion transfer, resulting in the production of inosine-5′-monophosphate (IMP) (Figure S4). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FASN | down-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15507492 |
Human fatty acid synthase (FAS) is a complex homodimeric (552-kDa) enzyme that regulates the de novo biosynthesis of long-chain fatty acids. This cytosolic enzyme catalyzes the formation of 16 carbon (C16) palmitate, from acetyl-coenzyme A (acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) in the presence of NADPH.  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
NADPH(4-) | up-regulates quantity
precursor of
|
NADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15507492 |
Human fatty acid synthase (FAS) is a complex homodimeric (552-kDa) enzyme that regulates the de novo biosynthesis of long-chain fatty acids. This cytosolic enzyme catalyzes the formation of 16 carbon (C16) palmitate, from acetyl-coenzyme A (acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) in the presence of NADPH.  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PGD | up-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
AKR1B1 | down-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7851421 |
Based on studies in mouse, ADKR1B1 catalyzes the conversion of alpha-D-galactose (a-Gal) to galactitol |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
NADPH(4-)