Relation Results

Summary

Name NADPH(4-)
Synonyms NADPH (UniProt), NADPH tetraanion (ChEBI)
IUPAC 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}
Formula C21H26N7O17P3
Primary ID CHEBI:57783
Type small molecule
Relations 10
Pathways Fatty Acid Synthesis, Pentose phosphate pathway

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Type: Score: Layout: SPV 
0.80.80.80.80.80.80.80.80.8NADP(3-)NADPH(4-)ME2FASNPGDME1G6PD

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Relations
Regulator
Mechanism
target
score ℹ
+ NADP(3-)up-regulates quantity img/direct-activation.png precursor of NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268078 Homo sapiens
pmid sentence
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP.
Identifier Residue Sequence Organism Cell Line
SIGNOR-268111 Homo sapiens
pmid sentence
6 PG undergoes oxidative decarboxylation by 6-phosphogluconate dehydrogenase (6PGD) producing Ru5P and the second NADPH molecule.
Publications: 2 Organism: Homo Sapiens
+ ME2up-regulates quantity img/direct-activation.png chemical modification NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267054 Homo sapiens
pmid sentence
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ NADPH(4-)up-regulates activity img/direct-activation.png binding FASN 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267371 Homo sapiens
pmid sentence
We determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH.
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ NADPH(4-)down-regulates activity img/direct_inhibition.png binding PGD 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267372 Homo sapiens
pmid sentence
We determined that FASN inhibitor treatment resulted in NADPH accumulation and inhibition of PGDH enzyme activity. NADPH is a cofactor utilized by FASN, also a known allosteric inhibitor of PGDH. PGDH is the onl yrate-limiting unidirectional enzyme susceptible to allosteric inhibition by NADPH
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ FASNdown-regulates quantity img/direct_inhibition.png chemical modification NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267759 Homo sapiens
pmid sentence
Human fatty acid synthase (FAS) is a complex homodimeric (552-kDa) enzyme that regulates the de novo biosynthesis of long-chain fatty acids. This cytosolic enzyme catalyzes the formation of 16 carbon (C16) palmitate, from acetyl-coenzyme A (acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) in the presence of NADPH. 
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ NADPH(4-)up-regulates quantity img/direct-activation.png precursor of NADP(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268088 Homo sapiens
pmid sentence
Human fatty acid synthase (FAS) is a complex homodimeric (552-kDa) enzyme that regulates the de novo biosynthesis of long-chain fatty acids. This cytosolic enzyme catalyzes the formation of 16 carbon (C16) palmitate, from acetyl-coenzyme A (acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) in the presence of NADPH. 
Publications: 1 Organism: Homo Sapiens
+ ME1up-regulates quantity img/direct-activation.png chemical modification NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267055 Homo sapiens
pmid sentence
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis, Pentose phosphate pathway
+ G6PDup-regulates quantity img/direct-activation.png chemical modification NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267052 Homo sapiens
pmid sentence
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ PGDup-regulates quantity img/direct-activation.png chemical modification NADPH(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267053 Homo sapiens
pmid sentence
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
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