| + |
SIRT6 | down-regulates activity 
deacetylation
|
ME1 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275572 |
Lys337 |
KIWLVDSkGLIVKGR |
|
|
| pmid |
sentence |
| 31735643 |
PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. |
|
| Publications: |
1 |
| + |
ACAT1 | up-regulates activity 
acetylation
|
ME1 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275571 |
Lys337 |
KIWLVDSkGLIVKGR |
|
|
| pmid |
sentence |
| 31735643 |
PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. |
|
| Publications: |
1 |
| + |
NEK1 | down-regulates activity
phosphorylation
|
ME1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275570 |
Ser336 |
KKIWLVDsKGLIVKG |
|
|
| pmid |
sentence |
| 31735643 |
PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. |
|
| Publications: |
1 |
| + |
PGAM5 | up-regulates activity
dephosphorylation
|
ME1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275569 |
Ser336 |
KKIWLVDsKGLIVKG |
|
|
| pmid |
sentence |
| 31735643 |
PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. |
|
| Publications: |
1 |
| + |
ME1 | up-regulates quantity
chemical modification
|
pyruvate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33064660 |
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
| + |
ME1 | down-regulates quantity
chemical modification
|
NADP(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33064660 |
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ME1 | up-regulates quantity
chemical modification
|
NADPH(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267055 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24769394 |
The major NADPH-producing enzymes in the cell are glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) in the pentose phosphate pathway (PPP), malic enzyme (ME) in the pyruvate cycling pathway, and isocitrate dehydrogenase (IDH) in the tricarboxylic acid (TCA) cycle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis, Pentose phosphate pathway |
| + |
ME1 | down-regulates quantity
chemical modification
|
(S)-malate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267717 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33064660 |
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Fatty Acid Synthesis |
4.0
ME1
- 
- 