| + |
PPAT | down-regulates quantity 
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9914248 |
Glutamine PRPP amidotransferase (GPATase) catalyzes the first step of de novo purine biosynthesis, the conversion of 5-phosphoribosyl-(~)l-pyrophosphate (PRPP) to 5-phosphoribosyl-([3)l-amine (PRA). The nitrogen source for the reaction is the amide group of glutamine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
D-ribofuranose 5-phosphate(2-) | up-regulates quantity 
precursor of
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267077 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267080 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
APRT | down-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15196008 |
In mammals, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) is present in all tissues and provides the only known mechanism for the metabolic salvage of adenine resulting from the polyamine biosynthesis pathway or from dietary sources. Phosphoribosyltransferases (PRTases) catalyze the displacement of a PRPP α-1‘-pyrophosphate through a nitrogen-containing nucleophile. The reaction products are a β-1-substituted ribose 5‘-phosphate and a free pyrophosphate (PP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
5-phospho-α-D-ribose 1-diphosphate | up-regulates quantity
precursor of
|
AMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15196008 |
In mammals, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) is present in all tissues and provides the only known mechanism for the metabolic salvage of adenine resulting from the polyamine biosynthesis pathway or from dietary sources. Phosphoribosyltransferases (PRTases) catalyze the displacement of a PRPP α-1‘-pyrophosphate through a nitrogen-containing nucleophile. The reaction products are a β-1-substituted ribose 5‘-phosphate and a free pyrophosphate (PP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
HPRT1 | down-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10338013 |
Hypoxanthine phosphoribosyltransferase @HGPRTase; EC 2.4.2.8; hypoxanthine pyrophosphate phosphoribosyltransferase# is a purine salvage enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between a-d-5-phosphoribosyl-1- pyrophosphate ~PRPP! and a purine base ~hypoxanthine or guanine! to form a purine nucleotide @inosine monophosphate ~IMP! or guanosine monophosphate ~GMP!#. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280475 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10338013 |
Hypoxanthine phosphoribosyltransferase @HGPRTase; EC 2.4.2.8; hypoxanthine pyrophosphate phosphoribosyltransferase# is a purine salvage enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between a-d-5-phosphoribosyl-1- pyrophosphate ~PRPP! and a purine base ~hypoxanthine or guanine! to form a purine nucleotide @inosine monophosphate ~IMP! or guanosine monophosphate ~GMP!#. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
5-phospho-α-D-ribose 1-diphosphate | up-regulates quantity
precursor of
|
guanosine 5'-monophosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10338013 |
Hypoxanthine phosphoribosyltransferase @HGPRTase; EC 2.4.2.8; hypoxanthine pyrophosphate phosphoribosyltransferase# is a purine salvage enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between a-d-5-phosphoribosyl-1- pyrophosphate ~PRPP! and a purine base ~hypoxanthine or guanine! to form a purine nucleotide @inosine monophosphate ~IMP! or guanosine monophosphate ~GMP!#. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
5-phospho-α-D-ribose 1-diphosphate | up-regulates quantity
precursor of
|
IMP |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10338013 |
Hypoxanthine phosphoribosyltransferase @HGPRTase; EC 2.4.2.8; hypoxanthine pyrophosphate phosphoribosyltransferase# is a purine salvage enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between a-d-5-phosphoribosyl-1- pyrophosphate ~PRPP! and a purine base ~hypoxanthine or guanine! to form a purine nucleotide @inosine monophosphate ~IMP! or guanosine monophosphate ~GMP!#. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
UMPS | down-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267437 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2912371 |
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
5-phospho-α-D-ribose 1-diphosphate | up-regulates quantity
precursor of
|
5-phospho-beta-D-ribosylaminium(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267292 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9914248 |
Glutamine PRPP amidotransferase (GPATase) catalyzes the first step of de novo purine biosynthesis, the conversion of 5-phosphoribosyl-(~)l-pyrophosphate (PRPP) to 5-phosphoribosyl-([3)l-amine (PRA). The nitrogen source for the reaction is the amide group of glutamine. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
5-phospho-α-D-ribose 1-diphosphate | up-regulates quantity
precursor of
|
orotidine 5'-phosphate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267435 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2912371 |
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
PRPS2 | up-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267082 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
PRPS1 | up-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
4.0
5-phospho-α-D-ribose 1-diphosphate