| + |
CDK1 | up-regulates activity 
phosphorylation
|
PRPS1 |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265728 |
Ser103 |
RQDKKDKsRAPISAK |
|
|
| pmid |
sentence |
| 31253668 |
CDK1 contributes to upregulation of PRPS1 activity by phosphorylating PRPS1 at S103|In conclusion, compared with upregulation of PRPS1 expression levels, increased PRPS1 activity, which is marked by S103 phosphorylation |
|
| Publications: |
1 |
| + |
AMPK | down-regulates activity 
phosphorylation
|
PRPS1 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265730 |
Ser180 |
GGAKRVTsIADRLNV |
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
PRPS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265729 |
Ser180 |
GGAKRVTsIADRLNV |
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS1 | down-regulates quantity by destabilization
phosphorylation
|
PRPS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276505 |
Ser285 |
EDKMKHCsKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
PRPS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276504 |
Ser285 |
EDKMKHCsKIQVIDI |
in vitro |
|
| pmid |
sentence |
| 34465890 |
Recruitment of TRAF2 to PRPS1/2 requires phosphorylation of PRPS1 S285 or PRPS2 T285, which is mediated by low stiffness-activated large tumor suppressor (LATS)1/2 kinases.LATS1/2-dependent S/T285 phosphorylation is required for PRPS1/2 ubiquitination and degradation at low stiffness. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
KHK | up-regulates activity
phosphorylation
|
PRPS1 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265735 |
Thr225 |
LVDDMADtCGTICHA |
|
|
| pmid |
sentence |
| 29074724 |
Ketohexokinase-A (KHK-A; also known as fructokinase-A) phosphorylates PRPS1 T225 and activates PRPS1 by blocking the binding of ADP, AMP, and GDP, which is required for hepatocellular carcinoma development |
|
| Publications: |
1 |
| + |
TBK1 | up-regulates activity
phosphorylation
|
PRPS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277316 |
Thr228 |
DMADTCGtICHAADK |
in vitro |
|
| pmid |
sentence |
| 34343500 |
Here, we show that ionizing radiation results in TBK1-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase (PRPS)1/2 at T228, thereby enhancing PRPS1/2 catalytic activity and promoting deoxyribonucleotide synthesis. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PRPS1 | up-regulates 
|
Nucleotide_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265733 |
|
|
Homo sapiens |
LK-87 Cell |
| pmid |
sentence |
| 29074724 |
We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
PRPS1 | up-regulates quantity
chemical modification
|
5-phospho-α-D-ribose 1-diphosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
PRPS1 | down-regulates quantity
chemical modification
|
D-ribofuranose 5-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267078 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16939420 |
PRPP (phosphoribosylpyrophosphate) is an important metabolite essential for nucleotide synthesis and PRS (PRPP synthetase) catalyses synthesis of PRPP from R5P (ribose 5-phosphate) and ATP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
AMP | down-regulates activity
chemical inhibition
|
PRPS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265737 |
|
|
|
|
| pmid |
sentence |
| 29074724 |
PRPS1 is inhibited by the nucleotide biosynthesis products ADP, AMP, and GDP |
|
| Publications: |
1 |
| + |
ADP | down-regulates activity
chemical inhibition
|
PRPS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265736 |
|
|
|
|
| pmid |
sentence |
| 29074724 |
PRPS1 is inhibited by the nucleotide biosynthesis products ADP, AMP, and GDP |
|
| Publications: |
1 |
| + |
GDP | down-regulates activity
chemical inhibition
|
PRPS1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265738 |
|
|
|
|
| pmid |
sentence |
| 29074724 |
PRPS1 is inhibited by the nucleotide biosynthesis products ADP, AMP, and GDP |
|
| Publications: |
1 |
3.0
PRPS1
- 
- 